tetrafluoroacetic acid | 359-46-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tetrafluoroacetic acid
• 英文别名: Acetyl hypofluorite；trifluoro-acetyl hypofluorite；Trifluor-acetylhypofluorit；trifluoroacetyl hypofluorite；trifluoroacetylhypofluorite；Trifluorperessigsaeure-fluorid；fluoro 2,2,2-trifluoroacetate
• CAS: 359-46-6
• 化学式: C₂F₄O₂
• 分子量: 132.014
• InChiKey: OXZOLXJZTSUDOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tetrafluoroacetic acid 、 4-acetyl-trans-stilbene 以 二氯甲烷 、 一氟三氯甲烷 为溶剂， 生成 threo-1-fluoro-2-(trifluoroacetoxy)-1-(4-acetophenyl)-2-phenylethane
  参考文献：
  名称：

  Synthesis and chemistry of trifluoroacetyl hypofluorite with elemental fluorine. A novel method for synthesis of .alpha.-fluorohydrins

  摘要：

  DOI：

  10.1021/jo01292a025
• 作为产物：
  描述：

  sodium 2,2,2-trifluoroacetate 在 fluorine 作用下， 以 various solvent(s) 为溶剂， 反应 6.0h， 生成 tetrafluoroacetic acid
  参考文献：
  名称：

  Synthesis and chemistry of trifluoroacetyl hypofluorite with elemental fluorine. A novel method for synthesis of .alpha.-fluorohydrins

  摘要：

  DOI：

  10.1021/jo01292a025
• 作为试剂：
  描述：

  Boc-O-苄基-L-酪氨酸 在 N-羟基丁二酰亚胺 、 tetrafluoroacetic acid 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 Boc-Arg(Tos)-Tyr(Bzl)-Leu-Pro-Thr-OBzl
  参考文献：
  名称：

  Konopinska, Danuta; Kazanowska, Bernarda; Sobotka, Wieslaw, Bulletin of the Polish Academy of Sciences: Chemistry, 1986, vol. 34, # 7-8, p. 327 - 331

  摘要：

  DOI：

文献信息

• Nucleotides and aptamers containing boronic acid groups having biased binding to glycosylated proteins, and uses thereof
  申请人：Wang Binghe

  公开号：US09096856B2

  公开（公告）日：2015-08-04

  The present disclosure encompasses oligonucleotide aptamers selectively binding a target glycosylated polypeptide or protein, and having biased affinity for the glycan through a boronic acid linked to a nucleosidic base of a nucleotide(s). The disclosure further encompasses methods for isolating an aptamer(s) selectively binding a target glycosylated polypeptide, where, from a population of randomized oligonucleotides that have at least one nucleotide having a boronic acid label linked to a base, is selected a first subpopulation of aptamers binding to the target glycosylated polypeptide or protein. This subpopulation is then amplified without using boronic acid-modified TTP, and amplification products not binding to a target glycosylated polypeptide or protein are selected. The second subpopulation of aptamers is then amplified using boronic acid-modified TTP to provide a population of boronic acid-modified aptamers capable of selectively binding to a glycosylation site of a target polypeptide or protein. Other aspects of the disclosure encompass methods for the use of the modified aptamers to detect glycosylated species of a polypeptide or protein.

  本公开涵盖了选择性结合目标糖基化多肽或蛋白质的寡核苷酸适配体，并且通过硼酸与一个或多个核苷酸碱基连接的方式对糖基具有偏倚亲和力。该公开还涵盖了一种用于分离选择性结合目标糖基化多肽的适配体的方法，其中从具有至少一个核苷酸具有硼酸标记连接到碱基的随机寡核苷酸群体中，选择了第一个结合到目标糖基化多肽或蛋白质的适配体亚群。然后，这个亚群体被放大，而不使用硼酸修饰的TTP，并选择不结合到目标糖基化多肽或蛋白质的放大产物。然后，使用硼酸修饰的TTP放大第二个适配体亚群，以提供一种能够选择性结合到目标多肽或蛋白质的糖基化位点的硼酸修饰适配体群体。该公开的其他方面涵盖了使用修改后的适配体来检测多肽或蛋白质的糖基化物种的方法。
• Glucocorticoid receptor modulators
  申请人：Abbott Laboratories

  公开号：US06583180B2

  公开（公告）日：2003-06-24

  Compounds of formula (I) or pharmaceutically acceptable salts thereof are novel glucocorticoid receptor modulators and are useful for treating type II diabetes in a mammal.

  式(I)的化合物或其药学上可接受的盐是新的糖皮质激素受体调节剂，并且对于治疗哺乳动物的II型糖尿病是有用的。
• Thermal Decomposition of Trifluoroacetyl Hypofluorite
  作者：Robert D. Stewart、George H. Cady

  DOI：10.1021/ja01628a005

  日期：1955.12
• Trifluoroacetyl Hypofluorite¹
  作者：George H. Cady、K. B. Kellogg

  DOI：10.1021/ja01106a504

  日期：1953.5
• Fluorination of (E)-.beta.-(Fluoromethylene)-m-Tyrosine: Regioselective Synthesis of 4-Fluoro-(E)-.beta.-(Fluoromethylene)-m-Tyrosine
  作者：Goran Lacan、N. Satyamurthy、Jorge R. Barrio

  DOI：10.1021/jo00106a038

  日期：1995.1

  Fluorination of (R)- and (S)-(E)-beta-(fluoromethylene)-m-tyrosine (1) by acetyl hypofluorite yielded a mixture of the corresponding 2-fluoro- (2a), 6-fluaro- (2b), 4-fluoro- (2c), and 2,6-difluoro- (2d) derivatives along with a pair of diastereomeric products of addition across the vinylic double bond. A regioselective synthesis of 4-fluoro-(E)-beta-(fluoromethylene)-m-tyrosine has also been developed based on a fluorodestannylation reaction with elemental fluorine followed by acid hydrolysis. This reaction sequence yielded minor byproducts, namely, 4-fluoro-(Z)-beta-(fluoromethylene)-m-tyrosine (II), 4,6-difluoro- and 2,4-difluoro-(E)-beta-(fluoromethylene)-m-tyrosines (12a and 12b). All these products were completely separated by semipreparative HPLC and fully characterized by NMR and mass spectroscopy. Single crystal X-ray crystallographic analyses of 2-fluoro-, 4-fluoro-, and 6-fluoro-(E)-beta-(fluoromethylene)-m-tyrosines unequivocally established the structures of these amino acids.