N-acryloylcarbazole | 2499-65-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-acryloylcarbazole
• 英文别名: 1-(9H-Carbazol-9-YL)prop-2-EN-1-one；1-carbazol-9-ylprop-2-en-1-one
• CAS: 2499-65-2
• 化学式: C₁₅H₁₁NO
• 分子量: 221.258
• InChiKey: VAXHNWJSQXUXMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-acryloylcarbazole 、 N-chloro-N-sodio-tert-butylcarbamate 以 二氯甲烷 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  一种利用次氯酸钠五水合物与简单氨基甲酸酯进行 α,β-不饱和羰基化合物氮丙啶化的实用方法

  摘要：

  简单的氨基甲酸叔丁酯与五水合次氯酸钠(NaOCl·5H 2 O)反应高效生成N-氯代-N-钠-氨基甲酸叔丁酯是一种实用且绿色的α,β氮丙啶化方法-不饱和羰基化合物。本文所述的方法不含过渡金属，所有材料均可商购，副产物（NaCl 和 H 2 O）对环境无害且反应具有立体选择性。所得氮丙啶是氨基酸的潜在前体。

  DOI：

  10.1039/d1ra04297a
• 作为产物：
  描述：

  N-(3-氯丙酰基)咔唑 在 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以71.71%的产率得到N-acryloylcarbazole
  参考文献：
  名称：

  Brar; Singh, Pravin Kumar, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 2006, vol. 45, # 3, p. 581 - 586

  摘要：

  DOI：

文献信息

• Porphyrin compositions
  申请人：Litz Erik Kyle

  公开号：US20060152149A1

  公开（公告）日：2006-07-13

  Novel metal porphyrin compositions useful as organic phosphors are provided. The novel compositions are prepared from commercially available porphyrin-containing starting materials. In one instance a novel palladium-containing porphyrin composition having a number average molecular weight of greater than 12,000 grams per mole was prepared from 5,10,15,20-tetrakis(3′,5′-di(hydroxy)phenyl)-21H-23H-porphyrin by reaction first with palladium(II) acetylacetonate, followed by reaction with 2-bromo-2-methylpropionyl bromide, and subsequent group transfer reaction of the alpha-bromo ester groups with 9,9-dioctyl-2-vinylfluorene in the presence of CuBr as a radical initiator. The product polymer exhibited a number average molecular weight of 12,884 grams per mole, a weight average molecular weight of 14,338 grams per mole, and a robust red phosphorescent emission. Porphyrin containing copoylmers comprising structural units derived from 9,9-dioctyl-2-vinylfluorene and 9-anthracenylmethyl methacrylate were prepared in a similar fashion.

  提供用作有机荧光体的新型金属卟啉组合物。这些新型组合物是从商业可获得的含卟啉起始原料制备的。在一个实例中，通过首先与醋酸钯(II)反应，然后与2-溴-2-甲基丙酰溴反应，并在CuBr存在下将α-溴酯基团与9,9-二辛基-2-乙烯基芴进行基团转移反应，制备了一个平均分子量大于12,000克/摩尔的新型含钯卟啉组合物，起始原料为5,10,15,20-四(3′,5′-二(羟基)苯基)-21H-23H-卟啉。该产物聚合物的平均分子量为12,884克/摩尔，重均分子量为14,338克/摩尔，具有稳健的红色磷光发射。类似地制备了含卟啉的共聚物，其结构单元源自9,9-二辛基-2-乙烯基芴和9-蒽甲基丙烯酸甲酯。
• CONJUGATED AROMATIC COMPOUND, OPTICAL MATERIAL, AND OPTICAL ELEMENT
  申请人：Saitoh Terunobu

  公开号：US20120330052A1

  公开（公告）日：2012-12-27

  The present invention relates to a conjugated aromatic compound represented by the Formula (1) in claim 1 (in the formula, Ar 1 represents a hydrogen atom or an aryl group optionally having a substituent; Ar 2 and Ar 3 each represent a hydrogen atom or an aryl group optionally having a substituent but at least one of Ar 2 and Ar 3 represents an aryl group optionally having a substituent; and A represents an aromatic hydrocarbon group) and relates to an optical material containing the conjugated aromatic compound. The conjugated aromatic compound and the optical material have characteristics of a high chromatic aberration correction function, high refractive-index dispersion characteristics (Abbe number (vd)) and high secondary dispersion characteristics (θg,F) (anomalous dispersion characteristics).

  本发明涉及一种由权利要求书中的式（1）表示的共轭芳香化合物（在该式中，Ar1代表氢原子或可选择具有取代基的芳基；Ar2和Ar3各自代表氢原子或可选择具有取代基的芳基，但至少Ar2和Ar3中的一个代表可选择具有取代基的芳基；A代表芳香烃基），并涉及包含该共轭芳香化合物的光学材料。该共轭芳香化合物和光学材料具有高色差校正功能、高折射率色散特性（阿贝数（vd））和高二次色散特性（θg，F）（异常色散特性）的特点。
• [EN] P53 MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE p53 ET UTILISATIONS DE CEUX-CI
  申请人：UNIV CALIFORNIA

  公开号：WO2021087096A1

  公开（公告）日：2021-05-06

  Described herein, inter alia, are p53 modulator compounds and methods of using the same. In an aspect is provided a p53 protein covalently bonded to a compound described herein. In an aspect is provided a pharmaceutical composition including a compound described herein and a pharmaceutically acceptable excipient. In an aspect is provided a method of treating cancer in a subject in need of such treatment, including administering to the subject an effective amount of a compound described herein.

  本文描述了p53调节剂化合物及其使用方法等内容。在一个方面，提供了一种p53蛋白与本文描述的化合物共价结合的方法。在一个方面，提供了一种包含本文描述的化合物和药用辅料的药物组合物。在一个方面，提供了一种治疗需要此类治疗的受试者的癌症的方法，包括向受试者施用本文描述的化合物的有效量。
• OPTICAL ELEMENT COMPOUND, OPTICAL MATERIAL, AND OPTICAL ELEMENT
  申请人：Saitoh Terunobu

  公开号：US20110288330A1

  公开（公告）日：2011-11-24

  An optical material organic compound having characteristics that the dispersion characteristic (Abbe number (ν d )) and the secondary dispersion characteristic (θg,F) of the refractive index are high, the transmittance in the visible light region is high, and the chromatic aberration correction function delivers high performance, which represented by the general formula (1) or (2) is provided.

  提供具有以下特征的光学材料有机化合物：折射率的色散特性（阿贝数（νd））和二次色散特性（θg,F）高，可见光区域的透射率高，色差校正功能性能高，其通用公式（1）或（2）表示。
• Modified copolymer of olefin and cycloolefin
  申请人：INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

  公开号：US20020061986A1

  公开（公告）日：2002-05-23

  The present invention provides an olefin/cycloolefin/alkylstyrene copolymer which is non-functionalized, functionalized, or grafted. By the functionalization of the benzylic protons of the alkylstyrene unit, the copolymer can be functionalized. The functionalized or grafted olefin/cycloolefin/alkylstyrene copolymer has good adhesion to a substrate and good compatibility with other polymers compared with the non-functionalized copolymer.

  本发明提供一种非官能化、官能化或接枝的烯烃/环烯烃/烷基苯乙烯共聚物。通过对烷基苯乙烯单元的苄基质子进行官能化，可以使共聚物官能化。与非官能化共聚物相比，官能化或接枝的烯烃/环烯烃/烷基苯乙烯共聚物具有良好的基材粘附性和与其他聚合物的良好相容性。