2-[2,3-Bis[2-(2-methylprop-2-enoyloxy)ethylcarbamoyloxy]propoxycarbonylamino]ethyl 2-methylprop-2-enoate | 149237-20-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[2,3-Bis[2-(2-methylprop-2-enoyloxy)ethylcarbamoyloxy]propoxycarbonylamino]ethyl 2-methylprop-2-enoate
• CAS: 149237-20-7
• 化学式: C₂₄H₃₅N₃O₁₂
• 分子量: 557.555
• InChiKey: OPNFAJABJPFTOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  39
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  194
• 氢给体数：
  3
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  1-硫代甘油 、 2-[2,3-Bis[2-(2-methylprop-2-enoyloxy)ethylcarbamoyloxy]propoxycarbonylamino]ethyl 2-methylprop-2-enoate 在 三乙胺 作用下， 以 二甲基亚砜 为溶剂， 以97.7%的产率得到
  参考文献：
  名称：

  Facile Synthesis of Polyester Dendrimers from Sequential Click Coupling of Asymmetrical Monomers

  摘要：

  Polyester dendrimers are attractive for in vivo delivery of bioactive molecules due to their biodegradability, but their synthesis generally requires multistep reactions with intensive purifications. A highly efficient approach to the synthesis of dendrimers by simply "sticking" generation by generation together is achieved by combining kinetic or mechanistic chemoselectivity with click reactions between the monomers. In each generation, the targeted molecules are the major reaction product as detected by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). The only separation needed is to remove the little unreacted monomer by simple precipitation or washing. This simple clicklike process without complicated purification is particularly suitable for the synthesis of custom-made polyester dendrimers.

  DOI：

  10.1021/ja9037406
• 作为产物：
  描述：

  甲基丙烯酸异氰基乙酯 、 甘油 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以97.6%的产率得到2-[2,3-Bis[2-(2-methylprop-2-enoyloxy)ethylcarbamoyloxy]propoxycarbonylamino]ethyl 2-methylprop-2-enoate
  参考文献：
  名称：

  Facile Synthesis of Polyester Dendrimers from Sequential Click Coupling of Asymmetrical Monomers

  摘要：

  Polyester dendrimers are attractive for in vivo delivery of bioactive molecules due to their biodegradability, but their synthesis generally requires multistep reactions with intensive purifications. A highly efficient approach to the synthesis of dendrimers by simply "sticking" generation by generation together is achieved by combining kinetic or mechanistic chemoselectivity with click reactions between the monomers. In each generation, the targeted molecules are the major reaction product as detected by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). The only separation needed is to remove the little unreacted monomer by simple precipitation or washing. This simple clicklike process without complicated purification is particularly suitable for the synthesis of custom-made polyester dendrimers.

  DOI：

  10.1021/ja9037406

文献信息

• MONOMER COMPOSITION FOR DENTAL MATERIALS, COMPOSITION FOR DENTAL MATERIALS, AND DENTAL MATERIAL
  申请人：MITSUI CHEMICALS, INC.

  公开号：US20210338537A1

  公开（公告）日：2021-11-04

  A monomer composition for a dental material including a compound represented by Formula (1). In Formula (1), X represents an n-valent organic group having from 1 to 200 carbon atoms and containing at least one selected from the group consisting of an oxygen atom and a nitrogen atom, in which the at least one selected from the group consisting of an oxygen atom and a nitrogen atom is bound to Y; and each Y represents a (meth)acryloyl group-containing group (Y1) represented by the following Formula (A), a (meth)acryloyl group (Y2), a hydrogen atom, or a hydrocarbon group having from 1 to 20 carbon atoms, with the proviso that at least one or more Y, among all Ys included in the compound represented by Formula (1), is the (meth)acryloyl group-containing group (Y1).
• Facile Synthesis of Polyester Dendrimers from Sequential Click Coupling of Asymmetrical Monomers
  作者：Xinpeng Ma、Jianbin Tang、Youqing Shen、Maohong Fan、Huadong Tang、Maciej Radosz

  DOI：10.1021/ja9037406

  日期：2009.10.21

  Polyester dendrimers are attractive for in vivo delivery of bioactive molecules due to their biodegradability, but their synthesis generally requires multistep reactions with intensive purifications. A highly efficient approach to the synthesis of dendrimers by simply "sticking" generation by generation together is achieved by combining kinetic or mechanistic chemoselectivity with click reactions between the monomers. In each generation, the targeted molecules are the major reaction product as detected by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). The only separation needed is to remove the little unreacted monomer by simple precipitation or washing. This simple clicklike process without complicated purification is particularly suitable for the synthesis of custom-made polyester dendrimers.