2,2-Dimethyl-propionic acid 4-(3H-imidazo[4,5-b]pyridin-2-yl)-2-methoxy-phenyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2,2-Dimethyl-propionic acid 4-(3H-imidazo[4,5-b]pyridin-2-yl)-2-methoxy-phenyl ester
• 英文别名: [4-(1H-imidazo[4,5-b]pyridin-2-yl)-2-methoxyphenyl] 2,2-dimethylpropanoate
• 化学式: C₁₈H₁₉N₃O₃
• 分子量: 325.367
• InChiKey: AIZMFEPJRRWUQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  77.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-dimethylpropionyl chloride 、 乙醚 、 4-(1H-imidazo[4,5-b]pyridin-2-yl)-2-methoxyphenol 生成 2,2-Dimethyl-propionic acid 4-(3H-imidazo[4,5-b]pyridin-2-yl)-2-methoxy-phenyl ester
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Ester derivatives of dimethylpropionic acid and pharmaceutical compositions containing them
  申请人：CERMOL S.A.

  公开号：EP1132381A1

  公开（公告）日：2001-09-12

  The present invention relates to esters of 2,2-dimethylpropionic acid having the general formula (I) or pharmacological acceptable salts thereof, as well as to pharmaceutical compositions containing said compounds and having an inhibitory activity of elastase.

  本发明涉及具有通式（I）的2,2-二甲基丙酸酯或其药理学上可接受的盐，以及含有该化合物并具有弹性蛋白酶抑制活性的药物组合物。
• [EN] ESTER DERIVATIVES OF DIMETHYLPROPIONIC ACID AND PHARMACETUICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES ESTERS D'ACIDE DIMETHYLPROPIONIQUE ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：CERMOL SA

  公开号：WO2001066526A1

  公开（公告）日：2001-09-13

  The present invnetion relates to esters of 2,2-dimethylpropionic acid having the general formula (I) or pharmacological acceptable salts thereof, as well as to pharmacetical ocmpositons containing said compounds and having an inhibitory activity of elastase.