Boc-Lys(Cbz)-OC16H33 | 794591-65-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Lys(Cbz)-OC16H33
• CAS: 794591-65-4
• 化学式: C₃₅H₆₀N₂O₆
• 分子量: 604.871
• InChiKey: OZRLNGRYSCKFQA-HKBQPEDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.0
• 重原子数：
  43.0
• 可旋转键数：
  24.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  102.96
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  Boc-Lys(Cbz)-OC16H33 在 palladium on activated charcoal TEA 、 氢气 作用下， 以 四氢呋喃 、 二氯甲烷 、 氯仿 为溶剂， 反应 19.0h， 生成 N-succinyl-Lys^inv-OC16H33
  参考文献：
  名称：

  Synthesis and biological activity of N-terminal lipidated and/or fluorescently labeled conjugates of astressin as corticotropin releasing factor antagonists

  摘要：

  This report describes the synthesis of eight N-terminally modified astressin analogs and their biochemical evaluation as corticotropin releasing factor (CRF) antagonists. The lipidated astressin derivatives were tested on rat CRF receptor type 1 and 2alpha and were found to be active as CRF antagonists (rCRFR1: pA(2) = 7.5-8.3; rCRFR2alpha: pA(2) = 7.5-9.0) with nearly equal activities as compared to unmodified astressin (rCRFR1: pA(2) = 8.3 +/- 0.09; rCRFR2alpha: pA(2) = 8.7 +/- 0.08). (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.07.035
• 作为产物：
  描述：

  1-十六烷醇 、 N-Boc-N'-Cbz-L-赖氨酸 在 4-二甲氨基吡啶 、 达卡巴嗪 作用下， 以 二氯甲烷 为溶剂， 反应 17.0h， 以88%的产率得到Boc-Lys(Cbz)-OC16H33
  参考文献：
  名称：

  Synthesis and biological activity of N-terminal lipidated and/or fluorescently labeled conjugates of astressin as corticotropin releasing factor antagonists

  摘要：

  This report describes the synthesis of eight N-terminally modified astressin analogs and their biochemical evaluation as corticotropin releasing factor (CRF) antagonists. The lipidated astressin derivatives were tested on rat CRF receptor type 1 and 2alpha and were found to be active as CRF antagonists (rCRFR1: pA(2) = 7.5-8.3; rCRFR2alpha: pA(2) = 7.5-9.0) with nearly equal activities as compared to unmodified astressin (rCRFR1: pA(2) = 8.3 +/- 0.09; rCRFR2alpha: pA(2) = 8.7 +/- 0.08). (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.07.035