乙酸异丁酸酐 | 7137-29-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 乙酸异丁酸酐
• 英文名称: acetyl 2-methyl propanoate
• 英文别名: isobutyric acetic anhydride；acetic isobutyric anhydride；isobutyryl acetate；Essigsaeure-isobuttersaeure-anhydrid；acetic acid isobutyric acid-anhydride；Isobuttersaeure-essigsaeure-anhydrid；methyl acetyl propionate；methylpropanoyl acetate；methylpropionyl acetate；acetyl 2-methylpropanoate
• CAS: 7137-29-3
• 化学式: C₆H₁₀O₃
• 分子量: 130.144
• InChiKey: VKVOKQTWSYMEAI-UHFFFAOYSA-N

物化性质

• 沸点：
  35.7-37.0 °C(Press: 5 Torr)
• 密度：
  0.994 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙酸异丁酸酐 、 苯 在 三氯化铝 作用下， 生成 异丁酰苯
  参考文献：
  名称：

  Williams; Dickert; Krynitsky, Journal of the American Chemical Society, 1941, vol. 63, p. 2511

  摘要：

  DOI：
• 作为产物：
  描述：

  乙烯酮 、 异丁酸 生成 乙酸异丁酸酐
  参考文献：
  名称：

  Mixed Carboxylic Anhydrides in the Friedel—Crafts Reaction¹

  摘要：

  DOI：

  10.1021/jo01038a017

文献信息

• [EN] GEL FORMULATIONS FOR ENHANCING THE EFFECT OF RADIOTHERAPY<br/>[FR] FORMULATIONS DE GEL POUR AMÉLIORER L'EFFET DE RADIOTHÉRAPIE
  申请人：UNIV DENMARK TECH DTU

  公开号：WO2016079331A1

  公开（公告）日：2016-05-26

  The present invention relates to a composition comprising: a. non-water soluble carbohydrates b. a contrast agent for imaging, wherein at least 60% of the contrast agent remains within 10 cm from the injection site after 24h, for use in local co-administration into a human or animal body, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration.

  本发明涉及一种包含以下成分的组成物：a. 非水溶性碳水化合物 b. 成像的对比剂，其中至少60%的对比剂在24小时后保持在注射部位10厘米范围内，用于在人体或动物体内局部共同给药，并且该组成物在给药前为液态，在给药后在粘度上增加超过1,000厘泊（cP）。
• [EN] PROCESS FOR THE PRODUCTION OF DIACYL PEROXIDES<br/>[FR] PROCÉDÉ DE PRODUCTION DE PEROXYDES DE DIACYLE
  申请人：NOURYON CHEMICALS INT BV

  公开号：WO2020249688A1

  公开（公告）日：2020-12-17

  Process for the production of a diacyl peroxide involving the reaction of an anhydride with hydrogen peroxide, removal of the formed carboxylic acid, production of an anhydride from said carboxylic acid, and recycling of the anhydride within the process.

  生产二酰过氧化物的过程涉及酐与过氧化氢的反应，去除形成的羧酸，从所述羧酸生产酐，并在过程中循环使用酐。
• Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and their use
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0463456A1

  公开（公告）日：1992-01-02

  Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure wherein R is OH, or salts thereof or lower alkoxy; Rx is H or alkyl; R1 is lower alkyl; R2 is lower alkyl; R3 is phenyl or substituted phenyl; and R4 is phenyl or substituted phenyl. New pharmaceutical compositions containing such compounds especially oral dosage forms, and use of such compounds for the preparation of a pharmaceutical composition to inhibit cholesterol biosynthesis are also described.

  提供了一种作为胆固醇生物合成抑制剂和降胆固醇药物有用的化合物，其结构为其中R为OH，或其盐或较低的烷氧基；Rx为H或烷基；R1为较低的烷基；R2为较低的烷基；R3为苯基或取代苯基；以及R4为苯基或取代苯基。还描述了含有这种化合物的新药物组合物，特别是口服剂型，以及利用这种化合物制备用于抑制胆固醇生物合成的药物组合物。
• [EN] NOVEL FXR (NR1H4 ) BINDING AND ACTIVITY MODULATING COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS SE LIANT AU FXR (NR1 H4) ET MODULANT SON ACTIVITÉ
  申请人：PHENEX PHARMACEUTICALS AG

  公开号：WO2011020615A1

  公开（公告）日：2011-02-24

  The present invention relates to compounds which bind to the NR1 H4 receptor (FXR) and act as agonists of the NR1 H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.

  本发明涉及结合NR1 H4受体（FXR）并作为NR1 H4受体（FXR）激动剂的化合物。该发明还涉及利用这些化合物制备药物用于通过这些化合物结合所述核受体治疗疾病和/或症状，并涉及这些化合物的合成过程。
• NEW ORTHO-FUNCTIONALIZED P-CHIRAL ARYLPHOSPHINES AND DERIVATIVES: THEIR PREPARATION AND USE IN ASYMMETRIC CATALYSIS
  申请人：Stephan Michel

  公开号：US20100099875A1

  公开（公告）日：2010-04-22

  The invention relates to novel organo phosphorus P-chiral optically active compounds of formula (I) having a hydroxyl, mercapto, amino, carboxyl, sulfonyl group on aryl near a phosphorus atom, to the preparation and the use thereof in then asymmetrical catalysis of unsaturated compounds. Novel acylphosphine optically pure ligands embodied in the form of transition metal complexes exhibit an increased activity and enantloselectivity, in particular in asymmetrical hydrogenation, in comparison with the same type Uganda such as DiPAMP.

  该发明涉及具有化学式（I）的新型有机磷P-手性光学活性化合物，其在含磷原子附近的芳基上具有羟基、巯基、氨基、羧基、磺酰基基团，以及其在不对称催化不饱和化合物中的制备和使用。新型酰基膦光学纯配体以过渡金属配合物的形式体现，与同类型的乌干达化合物（如DiPAMP）相比，在不对称氢化等反应中表现出增强的活性和对映选择性。