N¹,N⁸,N¹²-tris-tert-butoxycarbonylspermine | 99560-06-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N¹,N⁸,N¹²-tris-tert-butoxycarbonylspermine
• 英文别名: N¹,N⁸,N¹²-tris(tert-butoxycarbonyl)spermine；tert-butyl N-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]-N-[4-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propylamino]butyl]carbamate
• CAS: 99560-06-2
• 化学式: C₂₅H₅₀N₄O₆
• 分子量: 502.695
• InChiKey: AIOHFKGUNCJZIM-UHFFFAOYSA-N

物化性质

• 沸点：
  605.9±50.0 °C(Predicted)
• 密度：
  1.035±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  35
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N¹,N⁸,N¹²-tris-tert-butoxycarbonylspermine 在 镍 sodium hydroxide 、 氢气 、 碳酸氢钠 、 苯甲醚 、 三氟乙酸 作用下， 以 乙醇 、 水 为溶剂， 生成 2-N-[3-[3-aminopropyl-[4-(3-aminopropylamino)butyl]amino]propyl]-1,3,5-triazine-2,4,6-triamine
  参考文献：
  名称：

  An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes

  摘要：

  In this paper we describe an approach to selectively deliver compounds to trypanosomes using an adenosine transporter which is unique to the trypanosome. Various polyamine analogues have been attached to known substrates of this adenosine transporter. The compounds prepared interact specifically with the adenosine transporter, some with a similar efficiency to berenil, a known substrate. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00095-x
• 作为产物：
  描述：

  精胺 、 2-(叔丁氧羰基氧亚氨基)-2-苯乙腈 以 四氢呋喃 为溶剂， 反应 18.0h， 以72%的产率得到N¹,N⁸,N¹²-tris-tert-butoxycarbonylspermine
  参考文献：
  名称：

  新的二氢卟酚-多胺共轭物的合成及其光细胞毒性活性。

  摘要：

  本文报道了新的二氢卟酚-多胺偶联物的合成，旨在改善癌细胞的靶向性。测试了这些光敏剂对人慢性骨髓性白血病细胞（K562）的光细胞毒性活性，并与Photofrin II和二氢卟酚e6的作用进行了比较。

  DOI：

  10.1016/j.bmcl.2006.03.044

文献信息

• Chemistry of naturally occurring polyamines. 9. Synthesis of spermidine and spermine photoaffinity labeling reagents
  作者：Srinivasan Nagarajan、Bruce Ganem

  DOI：10.1021/jo00350a059

  日期：1985.12
• Polyamine conjugates of meso-tritolylporphyrin and protoporphyrin IX: Potential agents for photodynamic therapy of cancers
  作者：Vincent Sol、François Lamarche、Michaela Enache、Guillaume Garcia、Robert Granet、Michel Guilloton、J.C. Blais、Pierre Krausz

  DOI：10.1016/j.bmc.2005.09.071

  日期：2006.3

  An efficient five-step synthesis method was developed to obtain tritolylporphyrin and protoporphyrin IX polyamine conjugates. These compounds were composed of either one polyamine unit (spermidine or spermine) covalently tethered to monocarboxyphenyl tritolylporphyrin or two molecules of polyamines borne by protoporphyrin IX In each compound, an aliphatic spacer arm is linked to the N-4 polyamine position. Photocytotoxicity of these new compounds was evaluated against K562 human chronic myelogenous leukemia cells and compared to Photofrin II (R); protoporphyrin IX polyamine conjugates exhibited much stronger photocytocicity than Photofrin II (R) and were shown to readily induce necrosis in treated cells. (c) 2005 Elsevier Ltd. All rights reserved.
• [EN] COMPOSITIONS FOR THE DELIVERY OF PAYLOAD MOLECULES TO AIRWAY EPITHELIUM<br/>[FR] COMPOSITIONS POUR L'ADMINISTRATION DE MOLÉCULES DE CHARGE UTILE À L'ÉPITHÉLIUM DES VOIES RESPIRATOIRES
  申请人：MODERNATX INC

  公开号：WO2022032154A3

  公开（公告）日：2022-04-21
• [EN] LIPID AMINES<br/>[FR] AMINES LIPIDIQUES
  申请人：[en]MODERNATX, INC.

  公开号：WO2023076598A1

  公开（公告）日：2023-05-04

  Provided are lipid amine compounds which are useful in the preparation of lipid nanoparticle compositions for delivery of therapeutic or prophylactic payload into cells.