N-chloroacetyl-DL-methionine | 34366-37-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-chloroacetyl-DL-methionine
• 英文别名: N-Chloracetyl-DL-methionin；2-[(2-Chloroacetyl)amino]-4-methylsulfanylbutanoic acid
• CAS: 34366-37-5
• 化学式: C₇H₁₂ClNO₃S
• mdl: MFCD22122979
• 分子量: 225.696
• InChiKey: POPMMWHDENVQSV-UHFFFAOYSA-N

物化性质

• 沸点：
  481.9±45.0 °C(Predicted)
• 密度：
  1.324±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-chloroacetyl-DL-methionine 生成 Dithiophosphoric acid O,O'-diethyl ester S-[(1-methylcarbamoyl-3-methylsulfanyl-propylcarbamoyl)-methyl] ester
  参考文献：
  名称：

  New type of selectively acting organophosphorus insecticides and acaricides

  摘要：

  DOI：

  10.1007/bf00904989
• 作为产物：
  描述：

  氯乙酰氯 、 DL-蛋氨酸 生成 N-chloroacetyl-DL-methionine
  参考文献：
  名称：

  DIRECT ACYLATION OF α-AMINO ACIDS AND OF α-HYDROXY ACID DERIVATIVES

  摘要：

  DOI：

  10.1021/jo01130a002

文献信息

• Birnbaum et al., Journal of Biological Chemistry, 1952, vol. 194, p. 455,458
  作者：Birnbaum et al.

  DOI：——

  日期：——
• OLIGONUCLEOTIDE-MEDIATED SENSE CODON REASSIGNMENT
  申请人：The University of Queensland

  公开号：EP3775216A1

  公开（公告）日：2021-02-17
• [EN] OLIGONUCLEOTIDE-MEDIATED SENSE CODON REASSIGNMENT<br/>[FR] RÉASSIGNATION DE CODON SENS À MÉDIATION OLIGONUCLÉOTIDIQUE
  申请人：UNIV QUEENSLAND

  公开号：WO2019193416A1

  公开（公告）日：2019-10-10

  Sense codon reassignment to unnatural amino acids (uAAs) represents a powerful approach for introducing novel properties into polypeptides. The main obstacle to this approach is competition between the native isoacceptor tRNA(s) and orthogonal tRNA(s) for the reassigned codon. While several chromatographic and enzymatic procedures for selective deactivation of tRNA isoacceptors in cell-free translation systems exist, they are complex and not scalable. The present invention provides oligonucleotides that hybridise to a tRNA of interest when said tRNA is in a folded state, thereby disrupting the function of the tRNA. The present invention also provides the use of these oligonucleotides in methods for sense codon reassignment and methods for incorporation of uAAs into proteins. The approach described herein represents a new direction in genetic code reassignment with numerous practical applications.
• [EN] ASSAYS AND INHIBITORS OF OXYGEN-DEPENDENT N-TERMINAL OXIDATION<br/>[FR] DOSAGES ET INHIBITEURS DE L'OXYDATION N-TERMINALE DÉPENDANTE DE L'OXYGÈNE
  申请人：UNIV OXFORD INNOVATION LTD

  公开号：WO2020249946A1

  公开（公告）日：2020-12-17

  The invention relates to cyclised peptide or peptidomimetic inhibitors of cysteamine (2- aminoethanethiol) dioxygenase (ADO) and methods for identifying and producing inhibitors of ADO. The invention also relates to the use of inhibitors of ADO to modulate protein activity, stability and/or degradation, to treat conditions associated with hypoxia.