di-γ-glutamyl-cystine | 23052-19-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: di-γ-glutamyl-cystine
• 英文别名: N,N'-di-γ-glutamyl-cystine；N,N'-Di-γ-glutamyl-cystin；N,N'-Bis(gamma-glutamyl)cystine；2-amino-5-[[2-[[2-[(4-amino-4-carboxybutanoyl)amino]-2-carboxyethyl]disulfanyl]-1-carboxyethyl]amino]-5-oxopentanoic acid
• CAS: 23052-19-9
• 化学式: C₁₆H₂₆N₄O₁₀S₂
• 分子量: 498.535
• InChiKey: GOZJYXJJQVGDOJ-UHFFFAOYSA-N

物化性质

• 沸点：
  968.0±65.0 °C(Predicted)
• 密度：
  1.558±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -7.8
• 重原子数：
  32
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  310
• 氢给体数：
  8
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  di-γ-glutamyl-cystine 、 硫酸 生成 DL-胱氨酸
  参考文献：
  名称：

  Stewart; Tunnicliffe, Biochemical Journal, 1925, vol. 19, p. 211

  摘要：

  DOI：
• 作为产物：
  描述：

  gamma-glutamylcysteine 在 3,3,3-膦三基三丙酸 、 recombinant ovothiol A from Erwinia tasmaniensis 、 iron(II) sulfate 、 sodium chloride 、 D,L-histidine 作用下， 生成 di-γ-glutamyl-cystine
  参考文献：
  名称：

  Identification and Characterization of the First Ovothiol Biosynthetic Enzyme

  摘要：

  Ovothiols are histidine-derived thiols that were first isolated from marine invertebrates. We have identified a 5-histidylcysteine sulfoxide synthase (OvoA) as the first ovothiol biosynthetic enzyme and characterized OvoAs from Erwinia tasmaniensis and Trypanosoma cruzi. Homologous enzymes are encoded in more than 80 genomes ranging from proteobacteria to animalia.

  DOI：

  10.1021/ja109378e

文献信息

• Methods for conducting assays for enzyme activity on protein microarrays
  申请人：Zhou X. Fang

  公开号：US20050118665A1

  公开（公告）日：2005-06-02

  The present invention relates to methods of conducting assays for enzymatic activity on microarrays useful for the large-scale study of protein function, screening assays, and high-throughput analysis of enzymatic reactions. The invention relates to methods of using protein chips to assay the presence, amount, activity and/or function of enzymes present in a protein sample on a protein chip. In particular, the methods of the invention relate to conducting enzymatic assays using a microarray wherein a protein and a substance are immobilized on the surface of a solid support and wherein the protein and the substance are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the substance and the protein. The invention also relates to microarrays that have an enzyme and a substrate immobilized on their surface wherein the enzyme and the substrate are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the enzyme and the substrate.

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• Glutathione Disulfide Compositions and Related Methods for the Treatment of Cancer
  申请人：South Dakota Board of Regents

  公开号：US20160129070A1

  公开（公告）日：2016-05-12

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• US5206220A
  申请人：——

  公开号：US5206220A

  公开（公告）日：1993-04-27
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  申请人：——

  公开号：US7635572B2

  公开（公告）日：2009-12-22
• US9833486B2
  申请人：——

  公开号：US9833486B2

  公开（公告）日：2017-12-05