4-amino-2-ethylphenol | 178698-88-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-amino-2-ethylphenol
• CAS: 178698-88-9
• 化学式: C₈H₁₁NO
• mdl: MFCD16997606
• 分子量: 137.181
• InChiKey: ZWKXEALJTBALGD-UHFFFAOYSA-N

物化性质

• 沸点：
  287.0±28.0 °C(Predicted)
• 密度：
  1.115±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-amino-2-ethylphenol 以 四氢呋喃 、 甲醇 、 乙醇 为溶剂， 反应 48.5h， 生成 N-<3-<(diethylamino)methyl>-5-ethyl-4-hydroxyphenyl>acetamide
  参考文献：
  名称：

  Antimalarial drugs. 61. Synthesis and antimalarial effects of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-alkylphenols and their N.omega.-oxides

  摘要：

  A series of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-alkylphenols and their N omega-oxides were synthesized by the condensation of 4,7-dichloroquinoline and 4,7-dichloroquinoline N omega-oxide with appropriately substituted 4-amino-2-[(diethylamino)methyl]-6-alkylphenol dihydrochlorides. The latter precursors were prepared in a six-step synthesis starting from available 2-alkylphenols. Several of the title compounds display potent antimalarial activity in mice.

  DOI：

  10.1021/jm00388a027
• 作为产物：
  描述：

  乙基苯酚 在 盐酸 、 氢气 、 sodium nitrite 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， -5.0~20.0 ℃ 、300.01 kPa 条件下， 反应 4.0h， 生成 4-amino-2-ethylphenol
  参考文献：
  名称：

  [EN] PYRROLONE OR PYRROLIDINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
  [FR] ANTAGONISTES DU RÉCEPTEUR 1 D'HORMONE CONCENTRANT LA MÉLANINE DE TYPE PYRROLONE OU PYRROLIDINONE

  摘要：

  公开号：

  WO2014039412A8

文献信息

• [EN] IMIDAZOLIDINEDIONE DERIVATIVES<br/>[FR] DÉRIVÉS D'IMIDAZOLIDINEDIONE
  申请人：GLAXO GROUP LTD

  公开号：WO2011069951A1

  公开（公告）日：2011-06-16

  The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.

  这项发明提供了化合物(Ia)及其药学上可接受的盐。该发明还提供了将这些化合物或盐用作Kv3.1和/或Kv3.2的调节剂，以及在需要Kv3.1和/或Kv3.2调节剂的疾病或紊乱的治疗中的用途，如抑郁症和情绪障碍、听觉障碍、精神分裂症、物质滥用障碍、睡眠障碍或癫痫病。
• SUBSTITUTED 3-((3-AMINOPHENYL)AMINO)PIPERIDINE-2,6-DIONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
  申请人：Celgene Corporation

  公开号：US20200199074A1

  公开（公告）日：2020-06-25

  Provided herein are piperidine dione compounds having the following structure: wherein R N , R 1 , R 2 , R 3 , R 4 , X, L, V, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

  本文提供具有以下结构的哌啶二酮化合物： 其中R，R1，R2，R3，R4，X，L，V，m和n的定义如本文所述，包括有效量哌啶二酮化合物的组合物，以及治疗或预防雄激素受体介导疾病的方法。
• N-benzoyl urea compounds, antitumorous compositions containing them
  申请人：Ishihara Sangyo Kaisha Ltd.

  公开号：US04863924A1

  公开（公告）日：1989-09-05

  An N-benzoyl urea compound having the formula: ##STR1## wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is ##STR2## wherein Y.sub.1 is an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Y.sub.2 is a hydrogen atom, a halogen atom, a nitro group, an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Z is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and each of A and B is .dbd.CH-- or a nitrogen atom, provided that one of A and B is .dbd.CH-- and the other is a nitrogen atom, with the provisos (1) that when Q is ##STR3## where when X is a hydrogen atom and Y.sub.1 is an alkyl group, Z is not a hydrogen atom, a halogen atom nor a trifluoromethyl group, and (2) that when Q is ##STR4## wherein A is a nitrogen atom and Y.sub.1 is a trifluoromethyl group, Y.sub.2 is other than a hydrogen atom.

  一种具有以下化学式的N-苯甲酰脲化合物：其中X是氢原子、卤素原子或硝基基团，n是1到3之间的整数，Q是其中Y1是未取代或取代的烷基基团，或者是烷氧基或烷氧羰基基团，其烷基基团未取代或取代，Y2是氢原子、卤素原子、硝基基团、未取代或取代的烷基基团，或者是烷氧基或烷氧羰基基团，其烷基基团未取代或取代，Z是氢原子、卤素原子、三氟甲基基团或硝基基团，A和B中的每一个是.dbd.CH--或氮原子，前提是A和B中的一个是.dbd.CH--，另一个是氮原子，条件是（1）当Q是时，其中当X是氢原子且Y1是烷基时，Z不是氢原子、卤素原子或三氟甲基基团，以及（2）当Q是时，其中A是氮原子且Y1是三氟甲基基团时，Y2不是氢原子。
• [EN] HYDANTOIN DERIVATIVE<br/>[FR] DÉRIVÉ D'HYDANTOÏNE
  申请人：ONO PHARMACEUTICAL CO

  公开号：WO2021043245A1

  公开（公告）日：2021-03-11

  A compound represented by general formula (I-a) : has a strong DDR1 inhibitory activity, and can be a therapeutic agent for DDR1-related diseases, for example, a cancer, a kidney disease, a cardiovascular disease, a central nervous system disease, or fibrosis.

  一种由一般化学式（I-a）表示的化合物具有强大的DDR1抑制活性，可作为DDR1相关疾病的治疗药物，例如癌症、肾脏疾病、心血管疾病、中枢神经系统疾病或纤维化病。
• Synthesis and Anticoccidial Activities of Eight Novel Ethyl 7-Alkyl-6-(2-Aryloxyethoxy)-4-Hydroxyquinoline-3-Carboxylates
  作者：Chun-Rong Yan、Xing-Yan Zeng、Yuan-Peng Yao、Kui Nie、Yu-Liang Wang、Hua Chen

  DOI：10.3184/030823410x12651249924554

  日期：2010.2

  carboxylates were synthesised and their structures were identified by 1H NMR, MS, and IR spectra. The anticoccidial activities of these compounds were evaluated according to the ACI (the anticoccidial index) method. The results showed that two of these compounds exhibited anticoccidial activities against Eimeria tenella in the chicken’ diet with a dose of 27 mg kg−1.

  合成了八种新型 7-烷基-6-(2-芳氧基乙氧基)-4-羟基喹啉-3-羧酸乙酯，并通过 1 H 核磁共振、质谱和红外光谱鉴定了它们的结构。根据ACI（抗球虫指数）方法评价这些化合物的抗球虫活性。结果表明，其中两种化合物对鸡日粮中的艾美球虫表现出抗球虫活性，剂量为 27 mg kg-1。