N,N-(pyromellitoyl)-bis-L-methionine | 144443-38-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-(pyromellitoyl)-bis-L-methionine
• 英文别名: N,N'-(pyromellitoyl)-bis-L-methionine diacid；(2S)-2-[2-[(1S)-1-carboxy-3-methylsulfanylpropyl]-1,3,5,7-tetraoxopyrrolo[3,4-f]isoindol-6-yl]-4-methylsulfanylbutanoic acid
• CAS: 144443-38-9
• 化学式: C₂₀H₂₀N₂O₈S₂
• 分子量: 480.519
• InChiKey: TZKZODNPRCYAKP-KBPBESRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  200
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  N,N-(pyromellitoyl)-bis-L-methionine 在 氯化亚砜 作用下， 反应 5.0h， 生成 (2S,2'S)-2,2'-(1,3,5,7-tetraoxo-5,7-dihydropyrrolo[3,4-f]isoindole-2,6(1H,3H)-diyl)bis(4-(methylthio)butanoyl chloride)
  参考文献：
  名称：

  Darshan; Malhotra, Priti; Narula, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 6, p. 893 - 903

  摘要：

  DOI：
• 作为产物：
  描述：

  生成 N,N-(pyromellitoyl)-bis-L-methionine
  参考文献：
  名称：

  Novel nanostructure amino acid-based poly(amide–imide)s enclosing benzimidazole pendant group in green medium: fabrication and characterization

  摘要：

  In the present work, several novel optically active nanostructure poly(amide-imide)s (PAI)s were synthesized via step-growth polymerization reaction of chiral diacids based on pyromellitic dianhydride-derived dicarboxylic acids containing different natural amino acids such as l-alanine, S-valine, l-leucine, l-isoleucine, l-methionine, and l-phenylalanine with 2-(3,5-diaminophenyl)-benzimidazole under green conditions using molten tetrabutylammonium bromide. The new optically active PAIs were achieved in good yields and moderate inherent viscosity up to 0.41 dL/g. The synthesized polymers were characterized with FT-IR, H-1-NMR, X-ray diffraction, field emission scanning electron microscopy (FE-SEM), elemental and thermogravimetric analysis (TGA) techniques. These polymers show high solubility in organic polar solvents due to the presence of amino acid and benzimidazole pendant group at room temperature. FE-SEM results show that, these chiral nanostructured PAIs have spherical shapes and the particle size is around 20-80 nm. On the basis of TGA data, such PAIs are thermally stable and can be classified as self-extinguishing polymers. In addition due to the existence of amino acids in the polymer backbones, these macromolecules are not only optically active but also could be biodegradable and thus may well be classified under environmentally friendly materials.

  DOI：

  10.1007/s00726-012-1236-8

文献信息

• Synthesis, characterization and in vitro antimicrobial and biodegradability study of pseudo-poly(amino acid)s derived from N,N′-(pyromellitoyl)-bis-l-tyrosine dimethyl ester as a chiral bioactive diphenolic monomer
  作者：Shadpour Mallakpour、Farhang Tirgir、Mohammad R. Sabzalian

  DOI：10.1007/s00726-010-0686-0

  日期：2011.2

  N,N′-(pyromellitoyl)-bis-l-tyrosine dimethyl ester (7) as a chiral bioactive diphenolic monomer was prepared in three steps. The aim of this work was to obtain novel optically and biologically active pseudo-poly(amino acid)s (PAA)s that are more soluble in common organic solvents while maintaining their high thermal stability. Thus, several new, highly soluble, thermally stable, optically active and

  在该研究中N， ' - （pyromellitoyl） -双-升-酪氨酸甲酯（7），为手性的生物活性在三个步骤制备双酚单体。这项工作的目的是获得新型的光学和生物活性假聚（氨基酸）（PAA），它们在普通的有机溶剂中更易溶，同时保持其高的热稳定性。因此，通过使用甲苯磺酰氯，吡啶和N，N通过直接缩聚反应，制备了几种新的，高溶解性，热稳定，光学活性和可生物降解的主链中包含不同氨基酸部分的PAA，它们具有中等分子量。′-二甲基甲酰胺作为缩合剂。用FT-IR，1 H-NMR，元素和热重分析技术对所得的新型聚合物进行表征。此外，在培养基中对双酚单体7，不同的合成二酸（3a - 3e）和获得的PAA进行了体外毒性和生物降解性研究，结果表明合成的化合物和由其衍生的聚合物具有生物活性和可生物降解性。在自然环境下。
• Ultrasonic-assisted synthesis and characterization of layered double hydroxides intercalated with bioactive N,N′-(pyromellitoyl)-bis-l-α-amino acids
  作者：Shadpour Mallakpour、Mohammad Dinari、Vajiheh Behranvand

  DOI：10.1039/c3ra43645d

  日期：——

  In this study Mg/Al layered double hydroxides (LDHs) and organo-modified chiral LDHs were synthesized in one step under green conditions. Co-precipitation reaction of the Al(NO3)3·9H2O, Mg(NO3)2·6H2O and different biocompatible N,N-(pyromellitoyl)-bis-L-amino acids was carried out in aqueous solution in a short time by an ultrasonic technique. Field emission scanning electron microscopy and transmission electron microscopy techniques showed that the resulting products have good crystallinity and uniform morphology. The presence of the bioactive surfactants in the interlayer space of LDH was confirmed by Fourier transform infrared spectroscopy, X-ray diffraction (XRD) and thermogravimetry analysis techniques. As expected, the positions of the basal reflections in the XRD patterns of modified samples are shifted to higher d value indicating the expansion of the interlayer distance. Thermal properties were investigated by the thermogravimetric analysis technique.

  在这项研究中，镁/铝层状双氢氧化物（LDHs）和有机改性手性LDHs在绿色条件下一步合成。通过超声波技术，在水溶液中快速进行铝硝酸盐（Al(NO3)3·9H2O）、镁硝酸盐（Mg( )2·6H2O）和不同生物相容性N,N-(丙烯酰基)双-L-氨基酸的共沉淀反应。场发射扫描电子显微镜和透射电子显微镜技术表明，所得到的产品具有良好的结晶性和均匀的形态。通过傅里叶变换红外光谱、X射线衍射（XRD）和热重分析技术确认生物活性表面活性剂存在于LDH的层间空间中。如预期，改性样品的XRD图谱中的基面反射位置向较高的d值移动，表明层间距的扩大。热性能通过热重分析技术进行了研究。
• Effect of organically modified Ni–Al layered double hydroxide loading on the thermal and morphological properties of <scp>l</scp>-methionine containing poly(amide-imide) nanocomposites
  作者：Shadpour Mallakpour、Mohammad Dinari

  DOI：10.1039/c5ra03383g

  日期：——

  This work deals with the synthesis of an organically modified Ni–Al layered double hydroxide (LDH) and the effect of the LDH loading on the thermal and morphological behavior of poly(amide-imide)/Ni–Al LDH nanocomposites.

  这项工作涉及有机修饰的Ni-Al层状双氢氧化物（LDH）的合成，以及LDH负载对聚（酰胺-亚酰亚胺）/Ni-Al LDH纳米复合材料的热性能和形态行为的影响。