N,N'-bis(2-hydroxybenzyl)-L-cystine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-bis(2-hydroxybenzyl)-L-cystine
• 英文别名: Bn(2-OH)-Cys(1)-OH.Bn(2-OH)-Cys(1)-OH；(2R)-3-[[(2R)-2-carboxy-2-[(2-hydroxyphenyl)methylamino]ethyl]disulfanyl]-2-[(2-hydroxyphenyl)methylamino]propanoic acid
• 化学式: C₂₀H₂₄N₂O₆S₂
• 分子量: 452.552
• InChiKey: LBTQWZNKIZPRBQ-HOTGVXAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  30
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  190
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  L-胱氨酸 、 水杨醛 在 sodium hydroxide 、 sodium tetrahydroborate 作用下， 以 水 为溶剂， 反应 2.0h， 生成 N,N'-bis(2-hydroxybenzyl)-L-cystine
  参考文献：
  名称：

  CYSTINE DERIVATIVES AND INHIBITORS FOR THE ACTIVATION OF INFLAMMATORY FACTORS

  摘要：

  公开号：

  EP1364943B1

文献信息

• NOVEL CYSTINE DERIVATIVES AND INHIBITORS FOR THE ACTIVATION OF INFLAMMATORY FACTORS
  申请人：Ajinomoto Co., Inc.

  公开号：EP1364943A1

  公开（公告）日：2003-11-26

  A novel cystine derivative of a specific structure, such as N,N'-bis(2-hydroxybenzyl)-L-cystine (which may be in any form of free form, salt, solvate and the like) has been found to have an excellent action to suppress the activation of inflammatory factors. By using the derivative as an effective ingredient, an excellent agent for suppressing the activation of inflammatory factors can be provided. Additionally, the cystine derivative is preferably used for a method for suppressing the activation of inflammatory factors (in particular a method for preventing, ameliorating and/or therapeutically treating diseases (disorders), or skin injuries or disorders involved in the activation of inflammatory factors, a method for preventing, delaying, ameliorating and/or therapeutically treating skin change via aging or aesthetically unfavorable skin change as induced or promoted by inflammatory factors, and the like) and for pharmaceutical agents (pharmaceutical products; external skin application agents, eye drops, nutrition agents, transfusion and the like), cosmetics, foods or drinks and the like which are specific use applications to the agent for suppressing the activation of inflammatory factors. The invention also provides the novel cystine derivative with the excellent action to suppress the activation of inflammatory factors, which can be used as the effective ingredient described above, and a method for producing the same, and additionally provides the method for suppressing the activation of inflammatory factors described above, a use of the cystine derivative (active ingredient) described above for the agent for suppressing the activation of inflammatory factors, and the like.

  研究发现，一种具有特定结构的新型胱氨酸衍生物，如 N,N'-双（2-羟基苄基）-L-胱氨酸（可以是游离态、盐、溶液等任何形式），在抑制炎症因子活化方面具有出色的作用。通过使用该衍生物作为有效成分，可以提供一种抑制炎症因子活化的极佳制剂。此外，胱氨酸衍生物优选用于抑制炎症因子活化的方法（特别是预防、改善和/或治疗涉及炎症因子活化的疾病（失调）或皮肤损伤或失调的方法，预防、延缓、改善和/或治疗由炎症因子诱发或促进的皮肤老化或美观上不利的皮肤变化的方法等）和药物制剂（医药产品；外用皮肤涂抹剂、眼药水、营养剂、输血等）、化妆品、食品或饮料等，这些都是抑制炎症因子活化的药剂的特定用途应用。 本发明还提供了具有良好抑制炎症因子活化作用、可用作上述有效成分的新型胱氨酸衍生物及其生产方法，此外还提供了上述抑制炎症因子活化的方法、上述胱氨酸衍生物（有效成分）在抑制炎症因子活化制剂中的用途等。
• Novel cystine derivative and agent for suppressing activation of inflammatory factors
  申请人：AJINOMOTO CO., INC.

  公开号：US20040059110A1

  公开（公告）日：2004-03-25

  The present invention provides cystine derivatives, which may be in a free form, a salt form, a solvate form. The cystine derivatives of the present invention may be used to suppress activation of inflammatory factors. Accordingly, the present invention provides: compositions containing the cystine derivatives; a method for suppressing the activation of inflammatory factors by administering the composition; a method for preventing, ameliorating and/or therapeutically treating diseases, skin injuries or disorders involved in the activation of inflammatory factors by administering the composition; a method for preventing, delaying, ameliorating and/or therapeutically treating skin change via aging or aesthetically unfavorable skin change as induced or promoted by inflammatory factors by administering the composition; and pharmaceutical agents containing the cystine derivatives.

  本发明提供的胱氨酸衍生物可以是游离态、盐态、溶胶态。本发明的胱氨酸衍生物可用于抑制炎症因子的活化。因此，本发明提供：含有胱氨酸衍生物的组合物；通过施用该组合物抑制炎症因子活化的方法；通过施用该组合物预防、改善和/或治疗涉及炎症因子活化的疾病、皮肤损伤或失调的方法；通过施用该组合物预防、延迟、改善和/或治疗由炎症因子诱导或促进的通过衰老或美观上不利的皮肤变化的方法；以及含有胱氨酸衍生物的药剂。
• EP1364943A4
  申请人：——

  公开号：EP1364943A4

  公开（公告）日：2006-01-25
• US6914075B2
  申请人：——

  公开号：US6914075B2

  公开（公告）日：2005-07-05
• [EN] NOVEL CYSTINE DERIVATIVES AND INHIBITORS FOR THE ACTIVATION OF INFLAMMATORY FACTORS<br/>[FR] NOUVEAUX DERIVES DE CYSTINE ET INHIBITEURS DE L'ACTIVATION DES FACTEURS INFLAMMATOIRES
  申请人：AJINOMOTO KK

  公开号：WO2002062751A1

  公开（公告）日：2002-08-15

  Novel cystine derivatives represented by the following general formula (involving free compounds, salts, solvates, etc.) such as N,N'-bis(2-hydroxybenzyl)-L-cystine: (I) Use of these compounds having an excellent effect of inhibiting the activation of inflammatory factors makes it possible to provide favorable inhibitors for the activation. Thus, these derivatives are appropriately usable in methods of inhibiting the activation as described above (in particular, methods of preventing, ameliorating or treating illnesses (diseases) in association with the activation of inflammatory factors, skin damage and diseases, methods of preventing, retarding, ameliorating or treating changes in the skin due to aging or cosmetologically unfavorable changes in the skin induced or accelerated by inflammatory factors), drugs (medicines such as skin external preparations, eyedrops, supplements, transfusion preparations, etc.), cosmetics, drinks, foods, and so on.