1-[6-[2,3-Dioxo-4-(trifluoromethyl)indol-1-yl]hexyl]-4-(trifluoromethyl)indole-2,3-dione | 909529-46-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-[6-[2,3-Dioxo-4-(trifluoromethyl)indol-1-yl]hexyl]-4-(trifluoromethyl)indole-2,3-dione
• CAS: 909529-46-0
• 化学式: C₂₄H₁₈F₆N₂O₄
• 分子量: 512.408
• InChiKey: UBMPQUWWEMJOFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  1-[6-[2,3-Dioxo-4-(trifluoromethyl)indol-1-yl]hexyl]-4-(trifluoromethyl)indole-2,3-dione 以 乙醇 、 甲苯 为溶剂， 反应 8.0h， 生成 3-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-1'-[6-[3-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2',4-dioxo-4'-(trifluoromethyl)spiro[1,3-thiazolidine-2,3'-indole]-1'-yl]hexyl]-4'-(trifluoromethyl)spiro[1,3-thiazolidine-2,3'-indole]-2',4-dione
  参考文献：
  名称：

  Synthesis of Some Novel bis‐Spiro[indole‐pyrazolinyl‐thiazolidine]‐2,4′‐diones

  摘要：

  The reaction of 1H-indol-2,3-diones with 1,6-dibromohexane has resulted in the formation of new 1H-indol-2,3-diones-1,1'-(1,6-hexanediyl) bis in quantitative yields. These compounds have been used for the synthesis of novel [3'-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl) spiro[3H-indol-3,2'-thiazolidine]-2,4'-dione]1,1'-(1,6-hexanediyl) bis via bis Schiff's bases, [3-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl) imino-1H-indol-2-one]-1,1'-(1,6-hexanediyl)bis.

  DOI：

  10.1080/00397910600602560
• 作为产物：
  描述：

  1,6-二溴己烷 、 4-三氟甲基-1H-吲哚-2,3-二酮 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 以70%的产率得到1-[6-[2,3-Dioxo-4-(trifluoromethyl)indol-1-yl]hexyl]-4-(trifluoromethyl)indole-2,3-dione
  参考文献：
  名称：

  Synthesis of Some Novel bis‐Spiro[indole‐pyrazolinyl‐thiazolidine]‐2,4′‐diones

  摘要：

  The reaction of 1H-indol-2,3-diones with 1,6-dibromohexane has resulted in the formation of new 1H-indol-2,3-diones-1,1'-(1,6-hexanediyl) bis in quantitative yields. These compounds have been used for the synthesis of novel [3'-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl) spiro[3H-indol-3,2'-thiazolidine]-2,4'-dione]1,1'-(1,6-hexanediyl) bis via bis Schiff's bases, [3-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl) imino-1H-indol-2-one]-1,1'-(1,6-hexanediyl)bis.

  DOI：

  10.1080/00397910600602560

文献信息

• Synthesis of Some Novel bis‐Spiro[indole‐pyrazolinyl‐thiazolidine]‐2,4′‐diones
  作者：Manish Jain、Pankaj Khanna、Anjali Saxena、Sunita Bhagat、Carl E. Olsen、Subhash C. Jain

  DOI：10.1080/00397910600602560

  日期：2006.7

  The reaction of 1H-indol-2,3-diones with 1,6-dibromohexane has resulted in the formation of new 1H-indol-2,3-diones-1,1'-(1,6-hexanediyl) bis in quantitative yields. These compounds have been used for the synthesis of novel [3'-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl) spiro[3H-indol-3,2'-thiazolidine]-2,4'-dione]1,1'-(1,6-hexanediyl) bis via bis Schiff's bases, [3-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl) imino-1H-indol-2-one]-1,1'-(1,6-hexanediyl)bis.