pentafluorophenol 4-nitroxybutyrate | 838878-70-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: pentafluorophenol 4-nitroxybutyrate
• 英文别名: 4-(nitrooxy)butanoic acid pentafluorophenyl ester；4-nitrooxy-butanoic acid pentafluoro-phenyl ester；4-nitrooxy-butyric acid pentafluorophenyl ester；4-nitrooxybutanoic acid pentafluorophenol ester；pentafluorophenyl 4-(nitrooxy)butanoate；Perfluorophenyl 4-(nitrooxy)butanoate；(2,3,4,5,6-pentafluorophenyl) 4-nitrooxybutanoate
• CAS: 838878-70-9
• 化学式: C₁₀H₆F₅NO₅
• 分子量: 315.153
• InChiKey: PNERJLFIGBYJAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  81.4
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  pentafluorophenol 4-nitroxybutyrate 、 阿利克仑 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以45%的产率得到(2S,4S,5S,7S)-5-[4-(nitrooxy)butanoyl]amino-4-[4-(nitrooxy)butanoyl]oxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propopxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide
  参考文献：
  名称：

  WO2007/45551

  摘要：

  公开号：
• 作为产物：
  描述：

  4-bromobutanoic acid pentafluorophenyl ester 在 silver nitrate 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以80%的产率得到pentafluorophenol 4-nitroxybutyrate
  参考文献：
  名称：

  [EN] PROCESS FOR PREPARING NITROOXY ESTERS, NITROOXY THIOESTERS, NITROOXY CARBONATES AND NITROOXY THIOCARBONATES, INTERMEDIATES USEFUL IN SAID PROCESS AND PREPARATION THEREOF
  [FR] PROCEDE DESTINE A LA PREPARATION D'ESTERS NITRO-OXY, DE THIOESTERS NITRO-OXY, DE CARBONATES NITRO-OXY ET DE THIOCARBONATES NITRO-OXY, PRODUITS INTERMEDIAIRES UTILES DANS CE PROCEDE ET LEUR PREPARATION

  摘要：

  本发明涉及一种制备具有至少一个羟基或硫醇官能团的化合物的硝基酯、硝基硫酯、硝基碳酸酯和硝基硫代碳酸酯的过程，根据以下反应方案(I)、(II)、(III)。该发明还涉及在该过程中有用的中间体及其制备方法。

  公开号：

  WO2006008196A1

文献信息

• [EN] NEW NO-RELEASING STEROIDS FOR THE TREATMENT OF RETINA AND MACULA LUTEA DISEASES<br/>[FR] NOUVEAUX STÉROÏDES LIBÉRANT DU NO POUR LE TRAITEMENT DE MALADIES DE LA RÉTINE ET DE LA MACULA LUTEA
  申请人：NICOX SA

  公开号：WO2010015528A1

  公开（公告）日：2010-02-11

  The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof (formula1) The compounds are useful for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age- related macular degeneration and other diseases of retina and macula lutea.

  该发明涉及一般式(I)的化合物及其药学上可接受的盐或立体异构体（式1）。这些化合物可用于治疗糖尿病性黄斑水肿、糖尿病视网膜病变、黄斑退化、年龄相关性黄斑退化和其他视网膜和黄斑病。
• NITRIC OXIDE-RELEASING PRODRUG MOLECULE
  申请人：Zhejiang Huahai Pharmaceutical Co., Ltd

  公开号：EP3348548A1

  公开（公告）日：2018-07-18

  Provided are a type of compounds that can be used for treating cardiovascular diseases and compositions containing the compounds. The compounds and the compositions can improve lipid metabolism disorders by increasing high-density lipoprotein cholesterol in blood; in addition, the compounds and the compositions can also release nitric oxide, and reduce the onset risk of cardiovascular diseases by means of relaxing blood vessels, lowering blood pressure, inhibiting platelet adhesion and aggregation and maintaining vascular tension, and thus play an important role in preventing and treating the occurrence and development of cardiovascular diseases.

  提供一种可用于治疗心血管疾病的化合物和含有该化合物的组合物。该化合物和组合物可以通过增加血液中的高密度脂蛋白胆固醇来改善脂质代谢紊乱；此外，该化合物和组合物还可以释放一氧化氮，并通过放松血管、降低血压、抑制血小板粘附和聚集以及维持血管张力来降低心血管疾病的发病风险，从而在预防和治疗心血管疾病的发生和发展中发挥重要作用。
• Nitrate esters of aminoalcohols
  申请人：Herold Peter

  公开号：US20090318432A1

  公开（公告）日：2009-12-24

  The application relates to novel nitrate ester derivatives of substituted aminoalcohols of the general formula (I), wherein R 1 , R 2 , R 3 , V, X, Y and Z 0 have the meanings explained in more detail in the description, to a process for their preparation and to the use of these compounds as therapeutics in cardiovascular diseases, in particular in high blood pressure and vascular and organ damage age accompanying high blood pressure.

  该申请涉及一种新型硝酸酯衍生物，其为通式（I）中的取代氨基醇衍生物，其中R1、R2、R3、V、X、Y和Z0的含义在说明中有更详细的解释，以及它们的制备方法和将这些化合物作为治疗剂用于心血管疾病，特别是高血压和伴随高血压的血管和器官损伤的用途。
• Process for Preparing Nitrooxy Esters, Nitrooxy Thioesters Nitrooxy Carbonates and Nitrooxy Thiocarbinates, Intermediates Useful in Said Process and Preparation Thereof
  申请人：Almirante Nicoletta

  公开号：US20070238882A1

  公开（公告）日：2007-10-11

  The present invention relates to a process for preparing nitrooxy esters, nitrooxy thioesters, nitrooxy carbonates and nitrooxy thiocarbonates of compounds having at least an hydroxyl or thiol functional group, according to the following reaction scheme The invention also relates to intermediates useful in said process and to their preparation.

  本发明涉及一种制备至少具有羟基或硫醇官能团的化合物的硝氧酯、硝氧硫酯、硝氧碳酸酯和硝氧硫代碳酸酯的过程，如下反应方案所示。本发明还涉及该过程中有用的中间体及其制备方法。
• Nitoroxy derivatives of losartan, valsatan, candesartan, telmisartan, eprosartan and olmesartan as angiotensin-II receptor blockers for the treatment of cardiovascular diseases
  申请人：Almirante Nicoletta

  公开号：US20060276523A1

  公开（公告）日：2006-12-07

  Angiotensin II receptor blocker nitroderivatives of formula (I): R—(Y—ONO 2 ) s (I) having wider pharmacological activity and enhanced tolerability. They can be employed for treating cardiovascular, renal and chronic liver diseases and inflammatory processes.

  公式（I）的血管紧张素II受体阻滞剂硝基衍生物：R—（Y—ONO2）s（I），具有更广泛的药理活性和增强的耐受性。它们可用于治疗心血管、肾脏和慢性肝脏疾病以及炎症过程。