sodium 2-aminoethylthiolate | 51974-68-6

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: sodium 2-aminoethylthiolate
• 英文别名: Sodium;2-aminoethanethiolate
• CAS: 51974-68-6
• 化学式: C₂H₆NS*Na
• 分子量: 99.1321
• InChiKey: LJDOEHKIWLPKON-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氯化钒 、 sodium 2-aminoethylthiolate 以 乙腈 为溶剂， 以35%的产率得到
  参考文献：
  名称：

  Money, Joanna K.; Folting, Kirsten; Huffman, John C., Inorganic Chemistry, 1987, vol. 26, # 6, p. 944 - 948

  摘要：

  DOI：
• 作为试剂：
  描述：

  2-溴-2-甲基丙酸乙酯 在 sodium 2-aminoethylthiolate 作用下， 生成 2,2-dimethyl-3-oxothiomorpholine
  参考文献：
  名称：

  US2755278

  摘要：

  公开号：

文献信息

• Cyclodextrin-based polymers for therapeutics delivery
  申请人：Cheng Jianjun

  公开号：US09550860B2

  公开（公告）日：2017-01-24

  The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

  本发明涉及一种新型治疗环糊精含聚合物化合物的组合物，设计为小分子治疗药物的载体以及其制药组合物。这些含环糊精的聚合物提高了药物的稳定性和溶解性，并在体内使用时降低了小分子治疗药物的毒性。此外，通过从各种连接基团和靶向配体中选择，这些聚合物提供了治疗剂的控制释放方法。本发明还涉及使用所述治疗组合物治疗受试者的方法。本发明还涉及进行制药业务的方法，包括制造、许可或分发包含或与本文所述聚合物化合物相关的试剂盒。
• Imidazolemethylphosphonium salts
  申请人：SmithKline Corporation

  公开号：US04104472A1

  公开（公告）日：1978-08-01

  New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H.sub.2 antagonists.

  新的在2位具有可降解基团的咪唑甲基膦盐，可用作制备组织胺H.sub.2拮抗剂的中间体。
• COMPLEXING AGENTS FOR COMPOSITIONS CONTAINING INCLUSION COMPLEXES
  申请人：California Institute of Technology

  公开号：US20170049903A1

  公开（公告）日：2017-02-23

  The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:

  该发明提供了一种含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还包含一种络合剂。聚合物与络合剂在宿主-客体或客体-宿主相互作用中相互作用，形成包含复合物。该发明的治疗组合物可用于传递治疗剂并治疗各种疾病。颗粒复合物的聚合物和络合剂均可用于向治疗组合物引入功能。该发明还涉及一种制备组合物的方法。该方法将治疗剂、具有宿主或客体功能的聚合物以及具有客体或宿主功能的络合剂结合在一起，形成治疗组合物。络合剂与聚合物形成包含复合物。该发明还涉及一种传递治疗剂的方法。根据该方法，在确实需要治疗的已知需要治疗的哺乳动物（例如人或动物）体内给予该发明的治疗组合物的治疗有效量。还披露了具有以下结构的化合物：
• Helical transition-metal compounds: preorganisation of the ligands by a paracyclophane group
  作者：Peter Comba、Andreas Fath、Gottfried Huttner、Laszlo Zsolnai

  DOI：10.1039/cc9960001885

  日期：——

  The synthesis of a bis-diiminedithia substituted [2.2] paracyclophane, with a novel high-yielding [1 + 2] condensation reaction, and of its double helical dicopper(I) complex, characterized by a crystal structure analysis are reported.

  报道了一种双二亚胺硫替代的[2.2]对环戊烯的合成，该合成采用新型高产率的[1 + 2]缩合反应，以及其双螺旋二铜(I)配合物的晶体结构分析。
• Process for preparing 4-substituted imidazole compounds
  申请人：SK&F Lab Co.

  公开号：US04119781A1

  公开（公告）日：1978-10-10

  A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)methylimidazole compounds is disclosed.

  公开了一种通过从4-(三取代磷酸铵)甲基咪唑化合物中置换三取代磷酸铵基团来制备4-(氧、硫或氨基)甲基咪唑化合物的方法。