methacryloylamido-L-glutamic acid | 34373-07-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methacryloylamido-L-glutamic acid
• 英文别名: N-methacryloyl L-glutamic acid；Methacryloyl L-glutamic Acid；(2S)-2-(2-methylprop-2-enoylamino)pentanedioic acid
• CAS: 34373-07-4
• 化学式: C₉H₁₃NO₅
• 分子量: 215.206
• InChiKey: BCKKKQIAPZBSDV-LURJTMIESA-N

物化性质

• 熔点：
  130 °C
• 沸点：
  499.8±45.0 °C(Predicted)
• 密度：
  1.284±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methacryloylamido-L-glutamic acid 、 聚甘氨酸 、 sodium hydroxide 、 甲基丙烯酰氯 在 乙酸乙酯 作用下， 以 水 为溶剂， 生成 N-甲基丙烯酰基甘氨酸
  参考文献：
  名称：

  Glass-ionomer cements containing amino acids

  摘要：

  本发明涉及离子聚合物组合物和含有该组合物的离子聚合物水泥。该水泥可用于牙科和骨科医学。

  公开号：

  US20050165136A1
• 作为产物：
  描述：

  L-谷氨酸 、 甲基丙烯酰氯 在 氢氧化钾 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 methacryloylamido-L-glutamic acid
  参考文献：
  名称：

  Mineralization of Synthetic Polymer Scaffolds:  A Bottom-Up Approach for the Development of Artificial Bone

  摘要：

  The controlled integration of organic and inorganic components confers natural bone with superior mechanical properties. Bone biogenesis is thought to occur by templated mineralization of hard apatite crystals by an elastic protein scaffold, a process we sought to emulate with synthetic biomimetic hydrogel polymers. Cross-linked polymethacrylamide and polymethacrylate hydrogels were functionalized with mineral-binding ligands and used to template the formation of hydroxyapatite. Strong adhesion between the organic and inorganic materials was achieved for hydrogels functionalized with either carboxylate or hydroxy ligands. The mineral-nucleating potential of hydroxyl groups identified here broadens the design parameters for synthetic bonelike composites and suggests a potential role for hydroxylated Collagen proteins in bone mineralization.

  DOI：

  10.1021/ja043776z

文献信息

• DRUG DELIVERY VEHICLES, METHODS OF MANUFACTURE, AND METHODS OF USE THEREOF
  申请人：Thayumanavan Sankaran

  公开号：US20110200675A1

  公开（公告）日：2011-08-18

  Drug delivery vehicles that release one or more drugs, e.g., an opioid antagonist and/or an opioid, in response to changes in the chemistry of body fluids, specifically in response to changes in the partial pressure of CO 2 in the environment of the hydrogel are described. The drug delivery vehicles include hydrogels that swell or shrink in response to changes in the partial pressure of CO 2 in their environment, thus regulating release of an entrapped drug.

  本文描述了一种药物递送载体，该载体可以在体液化学变化，特别是在二氧化碳分压环境变化的情况下释放一个或多个药物，例如阿片拮抗剂和/或阿片类药物。这些药物递送载体包括水凝胶，水凝胶可以在其环境中二氧化碳分压的变化下膨胀或收缩，从而调节所包含药物的释放。
• Alpha, beta-unsaturated carbonyl modified amino acid monomer and
  申请人：Bausch & Lomb Incorporated

  公开号：US04663409A1

  公开（公告）日：1987-05-05

  Inclusion of carbonyl modified amino acid monomers in polymeric compositions for biomedical applications, including contact lenses, increases the water content and oxygen permeability of the polymer without significant changes in other desirable properties of the polymer.

  将羰基修饰的氨基酸单体纳入生物医学应用的聚合物组成中，包括隐形眼镜，可以提高聚合物的含水量和氧气渗透性，而不会对聚合物的其他理想性质造成显著影响。
• Polysiloxane composition with improved surface wetting characteristics and biomedical devices made thereof
  申请人：BAUSCH & LOMB INCORPORATED

  公开号：EP0124017A2

  公开（公告）日：1984-11-07

  The surface wetting characteristics of polysiloxanes prepared from monomeric polysiloxanes endcapped with activated unsaturated groups and modulus modifiers are improved by the inclusion of small amounts of an N-alkenoyl trialkylsilyl aminate. The improved polymeric compositions can be used to form hard, gas permeable contact lenses and other biomedical devices.

  通过加入少量的 N-烯酰基三烷基硅烷基氨基甲酸酯，可改善由端封有活化不饱和基团和模量调节剂的单体聚硅氧烷制备的聚硅氧烷的表面润湿特性。改进后的聚合物组合物可用于制造硬质透气隐形眼镜和其他生物医学设备。
• ADHESIVE COMPOSITION FOR DENTAL USE
  申请人：Tokuyama Dental Corporation

  公开号：EP2123246A1

  公开（公告）日：2009-11-25

  An adhesive composition for dental use exhibiting acidic property, including a mixture of a polymerizable monomer component (A) containing a phosphoric acid-type polymerizable monomer having an acidic group derived from phosphoric acid, and a multivalent metal ion-releasing component (B), wherein the multivalent metal ion-releasing component (B) is capable of releasing at least earth metal ions, and in the composition, earth metal ions stemming from the component (B) are present together with the phosphoric acid-type polymerizable monomer in such an amount that a total valency ratio (RE) defined by the following formula (1) is in a range of 0.2 to 3.0. The adhesive composition is capable of strongly adhering and fixing a composite resin or a prosthetic material to a tooth for extended periods of time maintaining stability. RE=TVE/TVA wherein TVE is a total valency of the earth metal ions contained in said composition, and TVA is a total valency of the acidic groups of the phosphoric acid-type polymerizable monomer contained in said composition.

  一种具有酸性的牙科用粘合剂组合物，包括含有磷酸型可聚合单体的可聚合单体组分（A）和多价金属离子释放组分（B）的混合物、其中，多价金属离子释放组分（B）至少能释放出土金属离子，在组合物中，由组分（B）产生的土金属离子与磷酸型可聚合单体一起存在，其含量为下式（1）定义的总价比（RE）在 0.2 至 3.0。该粘合剂组合物能够长时间将复合树脂或修复材料牢固地粘附和固定在牙齿上，并保持稳定。RE=TVE/TVA 其中 TVE 为所述组合物中所含土金属离子的总价，而 TVA 是所述组合物所含磷酸型可聚合单体的酸性基团的总价。
• DENTAL ADHESIVE COMPOSITION
  申请人：Tokuyama Dental Corporation

  公开号：EP2305205A1

  公开（公告）日：2011-04-06

  [Problems] A dental adhesive composition containing an acid group-containing polymerizable monomer, that can be used as a dental adhesive material or a primer. The dental adhesive composition has excellent durability of adhesion exhibiting further improved adhering strength and durability of adhesion enabling teeth to be more strongly adhered to a composite resin or a prosthetic over extended periods of time. [Means for Solution] The dental adhesive composition contains a polymerizable monomer and ions of an element of the Group IV as basic components, at least 10 mass% of the polymerizable monomer being a polymerizable monomer having a hydrogenphosphate diester group, such as bis(2-methacryloyloxyethyl)hydrogenphosphate or 2-methacryloyloxyethylphenyl hydrogenphosphate, and the content of ions of the element of the Group IV such as titanium ions or zirconium ions in the composition being 0.1 to 1.0 in terms of mole ratio to the hydrogenphosphate diester groups of the polymerizable monomer that has the hydrogenphosphate diester group.

  [问题] 一种牙科粘合剂组合物，含有一种含酸基团的可聚合单体，可用作牙科粘合材料或底漆。该牙科粘合剂组合物具有极佳的粘合耐久性，可进一步提高粘合强度和粘合耐久性，使牙齿能够长时间更牢固地粘合在复合树脂或修复体上。 [解决方法]该牙科粘合剂组合物含有作为基本成分的可聚合单体和第 IV 组元素离子，其中至少 10% 的可聚合单体是具有磷酸氢二酯基团的可聚合单体，例如双（2-甲基丙烯酰氧乙基）磷酸氢二酯或 2-甲基丙烯酰氧乙基苯基磷酸氢二酯，组合物中第 IV 组元素离子（例如钛离子或锆离子）的含量为 0.1 至 1.0 的摩尔比。