N-(1-氧代烯丙基)天冬氨酸 | 70714-77-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-(1-氧代烯丙基)天冬氨酸
• 中文别名: 过糖6b
• 英文名称: acryloyl L-aspartic acid
• 英文别名: acryloyl aspartic acid；N-Acryloyl-L-aspartic acid；(2S)-2-(prop-2-enoylamino)butanedioic acid
• CAS: 70714-77-1
• 化学式: C₇H₉NO₅
• 分子量: 187.152
• InChiKey: UILJLCFPJOIGLP-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  L-天门冬氨酸 、 丙烯酰氯 在 sodium carbonate 、 对苯二酚 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 4.5h， 以87%的产率得到N-(1-氧代烯丙基)天冬氨酸
  参考文献：
  名称：

  Synthesis and characterization of novel stimuli-responsive hydrogels based on starch and L-aspartic acid

  摘要：

  Starch is a hydrophilic biopolymer that is desirable in synthesizing new hydrogels. L-Aspartic acid is a multifunctional amino acid that can be used to modify starch in order to introduce new functional groups on its chains. In this research, a series of novel natural hydrogels based on starch and L-aspartic acid have been synthesized. These hydrogels exhibited temperature-responsive swelling behavior, pH sensitivity and superabsorbency properties. They were characterized by Nuclear Magnetic Resonance (NMR), Infra-Red Spectroscopy (IR), and X-ray Diffraction (XRD). The thermal properties of the hydrogels were evaluated using Thermo-Gravimetric Analysis (TGA) and Differential Scanning Calorimetery (DSC). Swelling studies were carried out at various temperatures and pHs. All of the hydrogels exhibited a high swelling ratio; in aqueous media, this value was greater at higher pH than at lower pH. These properties introduce a novel carrier having applications in delivery systems. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carbpol.2013.08.016

文献信息

• METHOD OF MAKING LIGAND FUNCTIONALIZED SUBSTRATES
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20170217880A1

  公开（公告）日：2017-08-03

  Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.

  本发明揭示了配体功能化基底、制备配体功能化基底的方法以及使用功能化基底的方法。
• AMINO ACID-BASED POLYMERIZABLE COMPOUNDS AND OPHTHALMIC DEVICES PREPARED THEREFROM
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20210388142A1

  公开（公告）日：2021-12-16

  Provided are amino acid based polymerizable compounds and their applications in ophthalmic devices. The amino acid based polymerizable compounds are of formula I: wherein R, R 1 , and R 2 are as described herein.

  提供了基于氨基酸的可聚合化合物及其在眼科设备中的应用。该基于氨基酸的可聚合化合物的化学式为I：其中R，R1和R2如本文所述。
• Glass-ionomer cements containing amino acids
  申请人：Mays Wayne Jimmy

  公开号：US20050165136A1

  公开（公告）日：2005-07-28

  Disclosed are ionomeric compositions and ionomeric cements containing the compositions. The cements are useful in dental and orthopedic medicine.

  本发明涉及离子聚合物组合物和含有该组合物的离子聚合物水泥。该水泥可用于牙科和骨科医学。
• LIGAND FUNCTIONAL SUBSTRATES
  申请人：Rasmussen Jerald K.

  公开号：US20120252091A1

  公开（公告）日：2012-10-04

  A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.

  提供了一种基底，它包括一个交联聚合物底漆层，并在其上接枝了一个配体功能化聚合物。接枝的聚合物具有必要的亲和力，可以在生物材料的pH值接近或低于其等电点时结合中性或负电荷的生物材料，例如细胞、细胞碎片、细菌、孢子、病毒、核酸和蛋白质。
• Azlactone-containing pressure-sensitive adhesives
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0128731A1

  公开（公告）日：1984-12-19

  Pressure-sensitive adhesives are prepared by the simultaneous polymerization of minor amounts of at least one alkenyl azlactone monomer and at least one arylic-functional carboxylic acid monomer, or precursors thereof, with a major amount of at least one acrylic monomer. The pressure-sensitive adhesives, after application to a substrate, will significantly increase in adhesion to the resultant bonded substrate after they are in the bonded configuration.

  压敏型粘合剂的制备方法是将少量的至少一种烯基氮内酯单体和至少一种丙烯酸官能团羧酸单体或其前体与大量的至少一种丙烯酸单体同时聚合。压敏粘合剂涂抹到基材上后，在粘合状态下，与粘合基材的粘合力会明显增强。