4-thiohexyluridine 5'-triphosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: 4-thiohexyluridine 5'-triphosphate
• 英文别名: [[(2R,3S,4R,5R)-5-(4-hexylsulfanyl-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C₁₅H₂₇N₂O₁₄P₃S
• 分子量: 584.372
• InChiKey: FDGABZCVLHJIBS-FMKGYKFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  35
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  268
• 氢给体数：
  6
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  2',3',5'-三乙酰尿苷 在 4-氯苯基二氯磷酸酯 作用下， 以 吡啶 、 ammonium hydroxide 、 乙醇 为溶剂， 反应 18.0h， 生成 4-thiohexyluridine 5'-triphosphate
  参考文献：
  名称：

  4-Substituted Uridine 5′-Triphosphates as Agonists of the P_2Y2Purinergic Receptor

  摘要：

  Uridine 5'-O-triphosphate (UTP) is a potent agonist of the purinergic receptor designated P-2Y2. UTP is rapidly metabolized in human tissue. To find a compound with similar activity that may be more slowly metabolized, a series of 4-substituted uridine 5'-triphosphates were prepared and evaluated in a P-2Y2 receptor second messenger assay.

  DOI：

  10.1080/07328319708006141

文献信息

• 4-Substituted Uridine 5′-Triphosphates as Agonists of the P_2Y2Purinergic Receptor
  作者：Sammy R. Shaver、William Pendergast、Suhaib M. Siddiqi、Benjamin R. Yerxa、Dallas K. Croom、Robert W. Dougherty、Michael K. James、A. Neil Jones、Janet L. Rideout

  DOI：10.1080/07328319708006141

  日期：1997.7

  Uridine 5'-O-triphosphate (UTP) is a potent agonist of the purinergic receptor designated P-2Y2. UTP is rapidly metabolized in human tissue. To find a compound with similar activity that may be more slowly metabolized, a series of 4-substituted uridine 5'-triphosphates were prepared and evaluated in a P-2Y2 receptor second messenger assay.