E,E-9,12-octadecadien-1-ol | 20063-91-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: E,E-9,12-octadecadien-1-ol
• 英文别名: (E,E)-linoleyl alcohol；9,12-octadecadien-1-ol；9E,12E-octadecadienol；octadeca-9,12-dien-1-ol；linoleyl alcohol；Δ^9.12-Linoleylalkohol；(9E,12E)-octadeca-9,12-dien-1-ol
• CAS: 20063-91-6
• 化学式: C₁₈H₃₄O
• 分子量: 266.467
• InChiKey: JXNPEDYJTDQORS-AVQMFFATSA-N

物化性质

• 沸点：
  374.0±11.0 °C(Predicted)
• 密度：
  0.858±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  E,E-9,12-octadecadien-1-ol 在 platinum(IV) oxide 、 溶剂黄146 作用下， 生成 硬脂醇
  参考文献：
  名称：

  Linoleyl Alcohol: Preparation and Some Properties

  摘要：

  DOI：

  10.1021/ja01268a016
• 作为产物：
  描述：

  亚油酸甲酯 在 乙醇 、 sodium 作用下， 生成 E,E-9,12-octadecadien-1-ol
  参考文献：
  名称：

  Kass; Burr, Journal of the American Chemical Society, 1940, vol. 62, p. 1797

  摘要：

  DOI：

文献信息

• Growth Hormone Secretagogue Receptor 1A Ligands
  申请人：Schambye Hans T.

  公开号：US20080300180A1

  公开（公告）日：2008-12-04

  The present invention relates to new growth hormone secretagogue receptor 1A (GHS-R 1A) ligands, and pharmaceutical compositions comprising any of the new GHS-R1 A ligands. The ligands are suitable for a wide range of applications, and thus the present invention also relates to use of the GHS-R1 A ligands according to the present invention in the manufacture of a medicament for the treatment of an individual in need thereof. In another aspect, the present invention relates to a method of treatment of an individual in need thereof, comprising administering to said individual one or more of the GHS-R1A ligands disclosed herein, such as e.g. for treatment of cancer cachexia.

  本发明涉及新型生长激素促分泌素受体1A（GHS-R 1A）配体，以及包含任何此类新型GHS-R1A配体的药物组合物。这些配体适用于广泛的应用范围，因此本发明还涉及根据本发明的GHS-R1A配体在制造用于治疗有此需要的个体的药物中的用途。在另一方面，本发明涉及一种治疗有此需要的个体的方法，包括向该个体施用本文披露的一种或多种GHS-R1A配体，例如用于治疗癌症恶病质。
• [EN] COMPLEX CATALYSTS BASED ON AMINO-PHOSPHINE LIGANDS FOR HYDROGENATION AND DEHYDROGENATION PROCESSES<br/>[FR] CATALYSEURS COMPLEXES À BASE DE LIGANDS DE TYPE AMINOPHOSPHINE POUR PROCESSUS D'HYDROGÉNATION ET DE DÉSHYDROGÉNATION
  申请人：GOUSSEV DMITRI

  公开号：WO2014139030A1

  公开（公告）日：2014-09-18

  The present application discloses novel PWNN and PWNWP metal catalysts for organic chemical syntheses including hydrogenation (reduction) of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate compounds includes esters, lactones, enals, enones, enolates, oils and fats, resulting in alcohols, enols, diols, and triols as reaction products. The catalysts of current application can be used to catalyze a hydrogenation reaction under solvent free conditions. The present catalysts also allow the hydrogenation to proceed without added base, and it can be used in place of the conventional reduction methods employing hydrides of the main-group elements. Furthermore, the catalysts of the present application can catalyze a dehydrogenation reaction under homogenous and/or acceptorless conditions. As such, the catalysts provided herein can be useful in substantially reducing cost and improving the environmental profile of manufacturing processes for a variety of chemicals.

  本申请披露了用于有机化学合成的新型PWNN和PWNWP金属催化剂，包括不饱和化合物的加氢（还原）或底物的脱氢。加氢底物化合物的范围包括酯，内酯，烯醛，烯酮，烯醇酸盐，油和脂肪，产生醇，烯醇，二醇和三醇作为反应产物。当前申请的催化剂可用于在无溶剂条件下催化加氢反应。目前的催化剂还允许加氢反应在无添加碱的情况下进行，并可用于取代使用主族元素氢化物的传统还原方法。此外，本申请的催化剂可以在均相和/或无受体条件下催化脱氢反应。因此，本文提供的催化剂可以在大幅降低成本和改善各种化学品制造过程的环境概况方面发挥作用。
• AQUEOUS COMPOSITION CONTAINING OMEGA-AMINO CARBOXYLIC ACID ESTERS AND FATTY ALCOHOL
  申请人：Evonik Degussa GmbH

  公开号：US20180344602A1

  公开（公告）日：2018-12-06

  The invention relates to aqueous compositions comprising ω-aminocarboxylic acid ester and fatty alcohol. The ω-aminocarboxylic acid esters may have the general formula 1, the general formula 2 and the general formula 3, as follows:

  这项发明涉及含有ω-氨基羧酸酯和脂肪醇的水性组合物。ω-氨基羧酸酯可能具有一般式1、一般式2和一般式3，如下所示：
• AGRICULTURAL PHEROMONE COMPOSITIONS COMPRISING POSITIONAL ISOMERS
  申请人：PROVIVI, INC.

  公开号：US20170135343A1

  公开（公告）日：2017-05-18

  The present disclosure provides pheromone compositions. In some aspects, the compositions taught herein comprise a pheromone chemically corresponding to the pheromone naturally produced by a given insect, along with at least one positional isomer of said pheromone. In various aspects, pheromone compositions of the present disclosure are able to modulate the response of the insect based on the ratio of natural pheromone to its positional isomer.

  本公开提供信息素组合物。在某些方面，本文所教授的组合物包括一种与某种昆虫自然产生的信息素在化学上相对应的信息素，以及至少一种该信息素的位置异构体。在各个方面，本公开的信息素组合物能够通过自然信息素与其位置异构体的比例来调节昆虫的反应。
• The synthesis of cholesteryl alkyl ethers
  作者：G. Halperin、S. Gatt

  DOI：10.1016/0039-128x(80)90109-9

  日期：1980.1

  Seventeen cholesteryl alkyl ethers were synthesized through alcoholysis of cholesterol p-toluenesulfonate. This method was found superior to the etherification of sodium or potassium cholesterylate with alkyl halides or methanesulfonates, especially for the preparation of long-chain unsaturated aklyl ethers of [7(m)-3H]cholesterol of high specific activity.

  通过胆固醇对甲苯磺酸的醇解合成了十七种胆固醇烷基醚。发现该方法优于胆甾醇钠或胆甾醇钾与烷基卤化物或甲磺酸盐的醚化，特别是用于制备高比活性的 [7(m)-3H] 胆固醇的长链不饱和烷基醚。

表征谱图