chloroacetyl hydroxamic acid methyl ester | 36851-81-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: chloroacetyl hydroxamic acid methyl ester
• 英文别名: N-methoxy-α-chloroacetamide；N-Methoxy-chloracetamid；2-chloro-N-methoxyacetamide
• CAS: 36851-81-7
• 化学式: C₃H₆ClNO₂
• mdl: MFCD11505358
• 分子量: 123.539
• InChiKey: QUWWITOOFIHCJI-UHFFFAOYSA-N

物化性质

• 密度：
  1.214±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  chloroacetyl hydroxamic acid methyl ester 在 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 7.0h， 生成 2-iodo-N-methoxyacetamide
  参考文献：
  名称：

  SUBSTITUTED OXIMES AS NEUROKININ ANTAGONISTS

  摘要：

  公开号：

  EP1032561B1
• 作为产物：
  描述：

  甲氧基胺盐酸盐 、 氯乙酰氯 在 trialkyl amine 作用下， 以80 %的产率得到chloroacetyl hydroxamic acid methyl ester
  参考文献：
  名称：

  对奎胺的不对称 [3+3] 环化用于合成 1,2,4-恶二嗪和氢喹喔啉

  摘要：

  已经开发出通过对奎胺与1,3-偶极替代羟肟酰卤和α-卤代羟肟酸酯的不对称[3+3]环加成高度非对映选择性合成不同杂环支架的通用且有效的策略。该合成方案提供了多种含有 1,2,4-恶二嗪和氢喹喔啉骨架的杂环结构，产率良好，底物范围广泛。

  DOI：

  10.1021/acs.orglett.3c04157

文献信息

• Compositions and methods of killing insects and acarids using
  申请人：Velsicol Chemical Corporation

  公开号：US03937824A1

  公开（公告）日：1976-02-10

  This invention discloses compounds of the formula ##EQU1## wherein R.sup.1 is alkyl; R.sup.2 is selected from the group consisting of hydrogen, alkyl, alkenyl, haloalkyl and cycloalkyl; R.sup.3 is selected from the group consisting of hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl and ##EQU2## WHEREIN D is selected from the group consisting of alkyl, alkenyl, alkoxy, alkylthio, halogen, haloalkyl, nitro and dialkylamino; and u is an integer from 0 to 3; X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are independently selected from the group consisting of oxygen and sulfur; m and n are each integers from 0 to 1; Z.sup.1 is selected from the group consisting of alkyl, alkenyl and ##EQU3## WHEREIN A is selected from the group consisting of alkyl, alkenyl, alkoxy, alkylthio, haloalkyl, halogen, nitro, alkylsulfoxide, alkylsulfone and dialkylamino; and q and p are each integers from 0 to 3; Z.sup.2 is selected from the group consisting of hydrogen and Z.sup.1, provided that when Z.sup.2 is hydrogen then n is zero; and Y is selected from the group consisting of alkyl, alkenyl, alkoxy, alkenyloxy, alkylthio, amino, alkylamino, dialkylamino and ##EQU4## WHEREIN E is selected from the group consisting of alkyl, alkenyl, alkoxy, alkylthio, halogen, nitro, alkylsulfoxide, alkylsulfone and dialkylamino; f is an integer from 0 to 3; Q is selected from the group consisting of oxygen, sulfur, alkylene, alkyleneoxy and alkylenethio; and t is an integer from 0 to 1. The above compounds are useful as insecticides and acaricides.

  这项发明揭示了以下结构的化合物：其中R.sup.1为烷基；R.sup.2选自氢、烷基、烯基、卤代烷基和环烷基组成的群；R.sup.3选自氢、烷基、烯基、卤代烷基、环烷基和的群；其中D选自烷基、烯基、烷氧基、烷硫基、卤素、卤代烷基、硝基和二烷基氨基组成的群；u为0到3的整数；X.sup.1、X.sup.2、X.sup.3和X.sup.4独立选自氧和硫；m和n各自为0到1的整数；Z.sup.1选自烷基、烯基和的群；其中A选自烷基、烯基、烷氧基、烷硫基、卤代烷基、卤素、硝基、烷基亚砜、烷基砜和二烷基氨基组成的群；q和p各自为0到3的整数；Z.sup.2选自氢和Z.sup.1，但当Z.sup.2为氢时，n为零；Y选自烷基、烯基、烷氧基、烯基氧基、烷硫基、氨基、烷基氨基、二烷基氨基和的群；其中E选自烷基、烯基、烷氧基、烷硫基、卤素、硝基、烷基亚砜、烷基砜和二烷基氨基组成的群；f为0到3的整数；Q选自氧、硫、烷基、烷基氧基和烷基硫基；t为0到1的整数。上述化合物可用作杀虫剂和杀螨剂。
• Facile synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones <i>via</i> cyclization of <i>N</i>-alkoxy α-halogenoacetamides with <i>N</i>-(2-chloromethyl)aryl amides
  作者：Qiaomei Jin、Dongjian Zhang、Jian Zhang

  DOI：10.1039/c9ob02260k

  日期：——

  A facile and efficient cyclization of N-alkoxy α-halogenoacetamides with N-(2-chloromethyl)aryl amides has been achieved for rapid access to 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-one derivatives (up to 95% yield). The intriguing features of this intermolecular cyclization include its mild reaction conditions and easy handling for scalable synthesis.

  N-烷氧基α-卤代乙酰胺与N-（2-氯甲基）芳基酰胺的简便有效环合已实现，可快速获得1,2,4,5-四氢-1,4-苯并二氮杂-3-one衍生物（最高可达95％）。这种分子间环化的有趣特征包括其温和的反应条件和易于操作的可扩展合成。
• Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino]
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04252802A1

  公开（公告）日：1981-02-24

  A compound of the formula ##STR1## wherein R is hydrogen, alkali metal, ##STR2## or ##STR3## R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen or methyl; R.sub.3 is hydrogen, lower alkyl or lower alkylphenyl; R.sub.4 is hydrogen, --OCONH.sub.2, ##STR4## R.sub.7 is hydrogen or lower alkyl; R.sub.8 is hydrogen or --CONH.sub.2 ; R.sub.9 is hydrogen, lower alkyl, ##STR5## or --(CH.sub.2).sub.p --N--(lower alkyl).sub.2 ; R.sub.10 is hydrogen or lower alkyl; R.sub.11 is hydrogen, sodium or potassium; n is 1, 2, 3 or 4; m is 0, 1 or 2; p is 1, 2, 3 or 4.

  化合物的公式为##STR1##其中R为氢、碱金属、##STR2##或##STR3##；R.sub.1为氢或甲基；R.sub.2为氢或甲基；R.sub.3为氢、较低的烷基或较低的烷基苯基；R.sub.4为氢、-OCONH.sub.2、##STR4##；R.sub.7为氢或较低的烷基；R.sub.8为氢或-CONH.sub.2；R.sub.9为氢、较低的烷基、##STR5##或-(CH.sub.2).sub.p--N--(较低的烷基).sub.2；R.sub.10为氢或较低的烷基；R.sub.11为氢、钠或钾；n为1、2、3或4；m为0、1或2；p为1、2、3或4。
• Cephalosporins having a carbamoylalkoxyiminoarylacetamido group at
  申请人：Glaxo Laboratories, Ltd.

  公开号：US04385177A1

  公开（公告）日：1983-05-24

  Antibiotic compounds of the general formula ##STR1## [wherein R is a phenyl, thienyl or furyl group; R.sup.a and R.sup.b, which may be the same or different, are each selected from hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl C.sub.3-7 cycloalkyl, phenyl, naphthyl, thienyl, furyl, carboxy, C.sub.2-5 alkoxycarbonyl and cyano, or R.sup.a and R.sup.b together with the carbon atom to which they are attached from a C.sub.3-7 cycloalkylidene or cycloalkenylidene group; R.sup.c is hydrogen or lower alkyl; R.sup.d is hydroxy, lower alkoxy, aralkoxy or aryloxy; m and n are each 0 or 1 such that the sum of m and n is 0 or 1; and P is selected from a hydrogen atom, a halogen atom and various organic groups] and non-toxic derivatives thereof.

  一般式为##STR1##的抗生素化合物[其中R为苯基，噻吩基或呋喃基; R.sup.a和R.sup.b，可以相同也可以不同，每个都选自氢，C.sub.1-4烷基，C.sub.2-4烯基，C.sub.3-7环烷基，苯基，萘基，噻吩基，呋喃基，羧基，C.sub.2-5烷氧基羰基和氰基，或者R.sup.a和R.sup.b与它们附着的碳原子一起形成一个C.sub.3-7环烷亚基或环烯亚基; R.sup.c为氢或较低的烷基; R.sup.d为羟基，较低的烷氧基，芳基烷氧基或芳基氧基; m和n分别为0或1，使得m和n的和为0或1; P选自氢原子，卤素原子和各种有机基团]及其非毒性衍生物。
• SUBSTITUTED OXIMES AS NEUROKININ ANTAGONISTS
  申请人：SCHERING CORPORATION

  公开号：EP1032561B1

  公开（公告）日：2004-02-11