2-[(1-羧基-异丙基)二硫烷基]-2-甲基丙酸 | 4695-30-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-[(1-羧基-异丙基)二硫烷基]-2-甲基丙酸
• 英文名称: 2-[(1-carboxy-isopropyl)disulfanyl]-2-methylpropanoic acid
• 英文别名: 2,2'-dimethyl-2,2'-dithiodipropionic acid；tetramethyl-3,4-dithia-adipic acid；Bis-(1-carboxy-1-methyl-aethyl)-disulfid；Tetramethyl-3,4-dithia-adipinsaeure；α.α'-Dithio-di-isobuttersaeure；Bis-(α-carboxy-isopropyl)-disulfid；Propanoic acid, 2,2'-dithiobis(2-methyl-；2-(2-carboxypropan-2-yldisulfanyl)-2-methylpropanoic acid
• CAS: 4695-30-1
• 化学式: C₈H₁₄O₄S₂
• 分子量: 238.329
• InChiKey: VZKRQCCMGBRZHG-UHFFFAOYSA-N

物化性质

• 熔点：
  197 °C
• 沸点：
  385.2±27.0 °C(Predicted)
• 密度：
  1.339±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[(1-羧基-异丙基)二硫烷基]-2-甲基丙酸 、 铬 在 高氯酸 、 乙二胺 作用下， 以 甲醇 、 高氯酸 为溶剂， 以40%的产率得到(2-methyl-2-mercaptopropionato-O,S)bis(ethylenediamine)chromium(III), perchlorate salt
  参考文献：
  名称：

  Kinetics and mechanism of the reaction of hydrogen peroxide with thiolato complexes of cobalt(III) and chromium(III). Comments on the nucleophilicity of coordinated sulfur and the stability of coordinated sulfenic acids

  摘要：

  DOI：

  10.1021/ic50207a052
• 作为产物：
  描述：

  2,2,5-trimethyl-3-oxo-3λ4-thia-adipic acid 生成 2-[(1-羧基-异丙基)二硫烷基]-2-甲基丙酸
  参考文献：
  名称：

  Larsson; Joensson, Chemische Berichte, 1934, vol. 67, p. 1267

  摘要：

  DOI：

文献信息

• First Examples of Oxidizing Aldehydes to Carboxylic Acids in the Presence of a Tertiary Disulfide Functional Group: Synthesis of Novel Diacid-disulfides
  作者：Xinqin Fang、Upul K. Bandarage、Tiansheng Wang、Joseph D. Schroeder、David S. Garvey

  DOI：10.1055/s-2003-37518

  日期：——

  The disulfide functionality exists in numerous organic compounds of interest in both chemistry and biology. In view of the fact that the disulfide function is highly susceptible to further oxidation by a broad range of agents, conducting a chemoselective oxidation without further oxidizing the disulfide group poses a synthetic challenge. Disclosed herein are the first examples of such an oxidation in which a series of aldehyde disulfides (1a-e) were converted to the corresponding symmetrical carboxylic acid disulfides (2a-e), utilizing sodium chlorite as the oxidant, and dimethyl sulf­oxide as both a reaction solvent and an efficient hypochlorous acid scavenger.

  二硫官能团存在于化学和生物学领域中许多令人感兴趣的有机化合物中。鉴于二硫功能极易被多种介质进一步氧化，在不进一步氧化二硫基团的情况下进行化学选择性氧化是一项合成挑战。本文公开了此类氧化的首个实例，利用亚氯酸钠作为氧化剂，二甲亚砜作为反应溶剂和有效的次氯酸清除剂，将一系列醛二硫化物（1a-e）转化为相应的对称羧酸二硫化物（2a-e）。
• Novel cytotoxic protein
  申请人：ZYMOGENETICS, INC.

  公开号：EP0286441A2

  公开（公告）日：1988-10-12

  Purified cytotoxic proteins for use within therapeu­tic compositions are disclosed. The proteins inhibit protein synthesis in vitro, exhibit abortifacient activity in mice, and contain proline residues with equivalent positions at residue 43 and residue 46 in ricin A-chain. A method for preparing such a cytotoxic protein from the tissue of Trichosanthes kirilowii is also disclosed. The proteins may also be used as active therapeutic substances, such as within a method for inhibiting protein synthesis in selected cells.

  本研究公开了用于治疗组合物的纯化细胞毒性蛋白质。这些蛋白质在体外抑制蛋白质合成，在小鼠体内表现出堕胎活性，并含有与蓖麻毒素 A 链中残基 43 和残基 46 位置相当的脯氨酸残基。还公开了一种从 Trichosanthes kirilowii 组织中制备这种细胞毒性蛋白质的方法。这些蛋白质还可用作活性治疗物质，例如用于抑制选定细胞中蛋白质合成的方法。
• Process for the removal of hydrogen sulfide and optionally carbon dioxide from gaseous streams
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0279667A2

  公开（公告）日：1988-08-24

  Hydrogen sulfide and/or carbon dioxide are removed from a sour gaseous stream in a contact zone by contacting the sour gaseous stream with H₂S- and/or CO₂- selective absorbent in an aqueous alkaline solution containing a polyvalent metal chelate at a pH of 7 to 10 wherein polyvalent metal chelate is in one embodiment of the invention in the reduced or lower valence state in a contact zone and is oxidized to the oxidized or higher valence state in an oxidation zone so as to convert hydrosulfide and/or sulfide salts present in the contact zone to sulfur. In a second embodiment, the aqueous alkaline solution and H₂S- and/or CO₂- selective absorbent in contact with the gaseous stream is a mixture containing a higher valence polyvalent metal chelate together with a lower valence polyvalent metal chelate, which lower valence polyvalent metal chelate is present in at least about five times the amount of the higher valence polyvalent metal chelant.

  硫化氢和/或二氧化碳从接触区的酸气流中去除，方法是将酸气流与 H₂S- 和/或 CO₂-在本发明的一个实施方案中，多价金属螯合物在接触区处于还原态或低价态，在氧化区被氧化为氧化态或高价态，从而将接触区中存在的硫化氢和/或硫化物盐转化为硫。在第二个实施方案中，与气态流接触的碱性水溶液和 H₂S- 和/或 CO₂- 选择性吸收剂是一种混合物，其中含有高价多价金属螯合物和低价多价金属螯合物，低价多价金属螯合物的含量至少约为高价多价金属螯合物的五倍。
• 465. Carbon–sulphur fission in thioethers. Part VI. The structural factors leading to either carbanion–sulphenium fission or α-proton extraction in p-nitrophenylmethylthio-acids
  作者：Youssef Iskander、Youssef Riad

  DOI：10.1039/jr9610002397

  日期：——
• Tananger, Arkiv foer Kemi, 1947, vol. 24 A, # 10, p. 4
  作者：Tananger

  DOI：——

  日期：——