N,O-dimethyltyrosine methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,O-dimethyltyrosine methyl ester
• 英文别名: N,O-Dimethyl-tyrosin-methylester；O.N-Dimethyl-dl-tyrosin-methylester；Methyl 3-(4-methoxyphenyl)-2-(methylamino)propanoate
• 化学式: C₁₂H₁₇NO₃
• 分子量: 223.272
• InChiKey: GZSRMIFFYCWUHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,O-dimethyltyrosine methyl ester 生成 3,6-bis-(4-methoxy-benzyl)-1,4-dimethyl-piperazine-2,5-dione
  参考文献：
  名称：

  Abderhalden; Schwab, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1925, vol. 148, p. 20

  摘要：

  DOI：
• 作为产物：
  描述：

  N-苄氧羰基-DL-酪氨酸 在 氢氧化钾 、 四丁基硫酸氢铵 、 三氟乙酸 作用下， 以 甲醇 、 乙醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.5h， 生成 N,O-dimethyltyrosine methyl ester
  参考文献：
  名称：

  Tamandarins A and B:  New Cytotoxic Depsipeptides from a Brazilian Ascidian of the Family Didemnidae

  摘要：

  The structures of two new, naturally occurring cytotoxic depsipeptides, tamandarins A and B (1 and 2), are presented. The tamandarins were isolated from an unidentified Brazilian marine ascidian of the family Didemnidae. The structures of the new cytotoxins were assigned by interpretation of FABMS data and by extensive 2D NMR analyses. The absolute configurations of the tamandarins were assigned by acid and alkaline hydrolysis to yield their corresponding amino acids, which were then analyzed as their Marfey derivatives. The cytotoxicity of tamandarin A (1) was evaluated against various human cancer cell lines and shown to be slightly more potent than didemnin B. A. qualitative discussion of the conformation of tamandarin A (1) in solution, obtained from NMR J-value data, variable temperature experiments, and NOESY/ROESY data, is included.

  DOI：

  10.1021/jo991425a

文献信息

• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• INHIBITORS OF PDE4 BINDING TO HSP20
  申请人：Baillie George S.

  公开号：US20130209439A1

  公开（公告）日：2013-08-15

  The present invention provides methods and materials for use in increasing HSP20 activation in a biological system, for example by increasing phosphorylation of Ser16 of HSP20. In one aspect, the invention provides a method for increasing HSP20 activation in a biological system, comprising contacting the system with an antagonist capable of inhibiting PDE4 binding to HSP20, the antagonist comprising or consisting essentially of a fragment of PDE4 or an analogue thereof. In a further aspect the invention provides a method of screening for an agent able to increase activation of HSP20. A preferred antagonist has a C-terminal lysine residue.
• US9034798B2
  申请人：——

  公开号：US9034798B2

  公开（公告）日：2015-05-19
• Abderhalden; Schwab, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1925, vol. 148, p. 20
  作者：Abderhalden、Schwab

  DOI：——

  日期：——
• Tamandarins A and B:  New Cytotoxic Depsipeptides from a Brazilian Ascidian of the Family Didemnidae
  作者：Hélène Vervoort、William Fenical、Rosângela de A. Epifanio

  DOI：10.1021/jo991425a

  日期：2000.2.1

  The structures of two new, naturally occurring cytotoxic depsipeptides, tamandarins A and B (1 and 2), are presented. The tamandarins were isolated from an unidentified Brazilian marine ascidian of the family Didemnidae. The structures of the new cytotoxins were assigned by interpretation of FABMS data and by extensive 2D NMR analyses. The absolute configurations of the tamandarins were assigned by acid and alkaline hydrolysis to yield their corresponding amino acids, which were then analyzed as their Marfey derivatives. The cytotoxicity of tamandarin A (1) was evaluated against various human cancer cell lines and shown to be slightly more potent than didemnin B. A. qualitative discussion of the conformation of tamandarin A (1) in solution, obtained from NMR J-value data, variable temperature experiments, and NOESY/ROESY data, is included.