Material Safety Data Sheet Section 1. Identification of the substance Product Name: 5-Amino-2h-isoquinolin-1-one Synonyms: Section 2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section 3. Composition/information on ingredients. Ingredient name: 5-Amino-2h-isoquinolin-1-one CAS number: 93117-08-9 Section 4. First aid measures Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section 5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section 6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution: Wear approved mask/respirator Hand precaution: Wear suitable gloves/gauntlets Skin protection: Wear suitable protective clothing Eye protection: Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section 7. Handling and storage Handling: This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section 8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section 9. Physical and chemical properties Appearance: Not specified Boiling point: No data No data Melting point: Flash point: No data Density: No data Molecular formula: C9H8N2O Molecular weight: 160.2 Section 10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section 11. Toxicological information No data. Section 12. Ecological information No data. Section 13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section 14. Transportation information Non-harzardous for air and ground transportation. Section 15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313.
Design, synthesis and biological activity of novel molecules designed to target PARP and DNA
作者:Elliot Goodfellow、Zhor Senhaji Mouhri、Christopher Williams、Bertrand J. Jean-Claude
DOI:10.1016/j.bmcl.2016.09.054
日期:2017.2
or 2 deficient tumours, we designed a series of molecules containing a 1,2,3-triazene moiety tethered to a PARP targeting scaffold. A cell-based selectivity assay involving a BRCA2-deficient Chinese hamster cell line and its corresponding BRCA2 wild type transfectant, was used to predict the PARP targeting potential of the latter agents. The results showed that adding a DNA damaging function to the PARP
N- and O-Alkylation of isoquinolin-1-ones in the Mitsunobu reaction: development of potential drug delivery systems
作者:Sandra Ferrer、Declan P. Naughton、Ifat Parveen、Michael D. Threadgill
DOI:10.1039/b109776h
日期:2002.1.23
Regioselective methods were investigated to prepare N- and O-alkylated isoquinolin-1-ones efficiently. The predicted regioselective alkylation of the nitrogen with (hetero)benzyl halides was complemented using (hetero)benzylic Mitsunobu electrophiles to alkylate predominantly at the oxygen. A series of drug-delivery conjugates was prepared demonstrating control over the site of alkylation. The Mitsunobu reaction provides a new approach to 1-alkoxyisoquinolines that were unavailable via previous harsher synthetic methods.
Rearranged pentanols, a process for their production and their use as anti-inflammatory agents
申请人:Rehwinkel Hartmut
公开号:US20050131226A1
公开(公告)日:2005-06-16
The invention relates to the compounds of formula I,
a process for their production and their use as anti-inflammatory agents.
这项发明涉及到式I的化合物,以及它们的生产过程和作为抗炎药物的用途。
[DE] UMGELAGERTE PENTANOLE, EIN VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ENTZÜNDUNGSHEMMER<br/>[EN] REARRANGED PENTANOLS, A METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS<br/>[FR] PENTANOLS REARRANGES, UN PROCEDE POUR LEUR PRODUCTION ET LEUR UTILISATION EN TANT QU'ANTI-INFLAMMATOIRES
申请人:SCHERING AG
公开号:WO2005035518A1
公开(公告)日:2005-04-21
Die Erfindung betrifft Verbindungen der Formel (I), ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer.
这项发明涉及公式(I)的化合物,其制备方法以及它们作为抗炎药物的用途。
[DE] TETRAHYDRONAPHTHALINDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ENTZÜNDUNGSHEMMER<br/>[EN] 1-AMINO-2-OXY-SUBSTITUTED TETRAHYDRONAPHTALENE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS<br/>[FR] DERIVES DE TETRAHYDRONAPHTALENE A SUBSTITUTION 1-AMINO-2-OXY, PROCEDES POUR LEUR PRODUCTION ET LEUR UTILISATION EN TANT QU'ANTI-INFLAMMATOIRES
申请人:SCHERING AG
公开号:WO2005034939A1
公开(公告)日:2005-04-21
Die Erfindung betrifft mehrfach substituierte Tetrahydronaphthalinderivate der Formel (I), Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer.