双十二烷基壬二酸酯 | 26719-99-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 双十二烷基壬二酸酯
• 英文名称: dilauryl azelate ester
• 英文别名: Azelainsaeure-didodecylester；didodecyl azelate；Nonanedioic acid, didodecyl ester；didodecyl nonanedioate
• CAS: 26719-99-3
• 化学式: C₃₃H₆₄O₄
• 分子量: 524.869
• InChiKey: JTJNOHFRNUDPDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.4
• 重原子数：
  37
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2917139000

反应信息

• 作为产物：
  描述：

  壬二酸 、 十二烷醇 在 lipase 作用下， 以 正己烷 为溶剂， 反应 6.0h， 生成 双十二烷基壬二酸酯
  参考文献：
  名称：

  Lipase-catalyzed synthesis of dilauryl azelate ester: process optimization by artificial neural networks and reusability study

  摘要：

  将人工神经网络（ANNs）应用于预测利普酶催化的双月桂基癸二酸酯酯化合成的性能。

  DOI：

  10.1039/c5ra16623c

文献信息

• Enhancing the Bioconversion of Azelaic Acid to Its Derivatives by Response Surface Methodology
  作者：Nurshafira Khairudin、Mahiran Basri、Hamid Fard Masoumi、Shazwani Samson、Siti Ashari

  DOI：10.3390/molecules23020397

  日期：——

  Azelaic acid (AzA) and its derivatives have been known to be effective in the treatment of acne and various cutaneous hyperpigmentary disorders. The esterification of azelaic acid with lauryl alcohol (LA) to produce dilaurylazelate using immobilized lipase B from Candida antarctica (Novozym 435) is reported. Response surface methodology was selected to optimize the reaction conditions. A well-fitting

  已知壬二酸 (AzA) 及其衍生物可有效治疗痤疮和各种皮肤色素沉着过度疾病。报道了使用来自南极念珠菌 (Novozym 435) 的固定化脂肪酶 B 将壬二酸与月桂醇 (LA) 酯化以产生二月桂酸酯。选择响应面方法来优化反应条件。关于几个参数，包括反应时间和温度、酶量和底物摩尔比，建立了用于酸转化的拟合良好的二次多项式回归模型。通过RSM中心复合设计得到的回归方程预测，最佳反应条件为反应时间360 min、酶用量0.14 g、反应温度46℃、底物摩尔比1:4.1。模型结果与实验数据吻合较好，均在实验范围内（R2为0.9732）。抑制区可见于直径9.0±0.1 mm的二月桂酸酯对表皮葡萄球菌S273的活性。正常成纤维细胞系 (3T3) 用于评估 AzA 和 AzA 衍生物（二月桂酸酯）的细胞毒性活性。证明了 AzA 和 AzA 衍生物的 IC50（细胞活力的 50% 抑制）值的比较。AzA 的
• ESTER OILS
  申请人：Lämmle Patrick

  公开号：US20130190217A1

  公开（公告）日：2013-07-25

  According to a first aspect, an ester oil, in particular for producing a hydraulic fluid and/or a lubricant, containing an esterification product from the esterification of at least one monoalcohol with at least one polycarboxylic acid, is characterized in that the monoalcohol and/or the polycarboxylic acid originates from renewable raw materials. According to a second aspect, an ester oil, in particular for producing a hydraulic fluid and/or a lubricant, containing an esterification product from the esterificati-on of at least one monocarboxylic acid with at least one dialcohol, is characterized in that the dialcohol and/or the monocarboxylic acid originates from renewable raw materials.

  根据第一方面，一种酯类油，特别用于生产液压油和/或润滑剂，其中包含至少一种单醇与至少一种多羧酸酯化产物的酯化产物，其特征在于单醇和/或多羧酸来源于可再生原材料。根据第二方面，一种酯类油，特别用于生产液压油和/或润滑剂，其中包含至少一种单羧酸与至少一种双醇酯化产物的酯化产物，其特征在于双醇和/或单羧酸来源于可再生原材料。
• Thermochromic opaque composition and uses thereof
  申请人：THE PILOT INK CO., LTD.

  公开号：EP0595577A2

  公开（公告）日：1994-05-04

  There are provided a thermochromic opaque composition capable of exhibiting change in transparency together with change in color in response to temperature variation, a laminate member employing the same, and a three-dimensional article capable of concealing and revealing the interior, utilizing the laminate member. The thermochromic opaque composition is formed by dispersing a thermochromic material, capable of developing and erasing color by an electron donating-accepting reaction, in small particles in vinyl chloride-vinyl acetate matrix resin. The above-mentioned structure realizes reversible change in transparency, together with change in color, in response to temperature variation, with hysteresis with a temperature difference of 10°C at minimum to 50°C between the high and low trigger temperatures.

  本发明提供了一种热致变色不透明组合物，该组合物能够随着温度的变化而显示出透明度的变化以及颜色的变化，还提供了一种使用该组合物的层压件，以及一种利用该层压件能够隐藏和显示内部的三维物品。 热致变色不透明组合物是通过将热致变色材料分散在氯乙烯-醋酸乙烯基质树脂的小颗粒中形成的，这种材料能够通过电子捐献-接受反应显色和消色。 上述结构可随着温度的变化实现透明度的可逆变化以及颜色的变化，并具有滞后性，触发温度的高低温差最小为 10°C，最大为 50°C。
• Opaque/transparent thermochromic compositions and laminate
  申请人：THE PILOT INK CO., LTD.

  公开号：EP0677564A2

  公开（公告）日：1995-10-18

  A thermochromic opaque/transparent composition is capable of exhibiting change in transparency together with change in color in response to temperature variation, a laminate member employing the same, and a three-dimensional article capable of concealing and revealing the interior, utilizing the laminate member. A thermochromic opaque/transparent composition is composed of dispersion, in vinyl chloridevinyl acetate copolymer matric resin, which has been obtained by blending with hindered amine compound selected from piperidine derivatives within a particle size range of 0.1 to 2.0 µm, of a reversible thermochromic material consisting of (a) an electron-donating color-developing organic compound, (b) a compound having a phenolic hydroxyl radical, and (c) a homogeneous fused composition containing a compound selected from alcohols, esters, ketones and carboxylic acids, and capable of exhibiting reversible change in transparency together with change in color in response to temperature variation, with hysteresis with a temperature difference of 10°C to 50°C between the low and high trigger temperatures.

  一种热致变色不透明/透明组合物能够随着温度的变化而显示出透明度的变化以及颜色的变化，一种使用该组合物的层压件，以及一种利用该层压件能够隐藏和显示内部的三维物品。 热致变色不透明/透明组合物是由分散在氯乙烯乙烯基醋酸酯共聚物母树脂中的可逆性胺化合物和选自哌啶衍生物的受阻胺化合物在 0.1 至 2.这种可逆热致变色材料包括：(a) 电子捐赠显色有机化合物；(b) 具有酚羟基的化合物；(c) 含有选自醇、酯、酮和羧酸的化合物的均质熔融组合物。
• Thermochromic microencapsulated pigments
  申请人：THE PILOT INK CO., LTD.

  公开号：EP1084860A2

  公开（公告）日：2001-03-21

  Disclosed is a thermochromic microencapsulated pigment which comprises as four essential components (a) an electron-donating chromatic organic compound, (b) an electron-accepting compound, (c) a reaction medium determining the temperatures at which the color reactions of component (a) with component (b) take place, and (d) a color change temperature regulator, the color change temperature regulator (d) comprising one or more compounds selected from the group consisting of esters, alcohols, ketones, acid amides, hydrocarbons, and fatty acids and having a melting point Y (°C) satisfying the relationship (X+30)°C≤Y≤200°C, wherein X (°C) is the melting point of component (c), and the four essential components being microencapsulated.

  本发明公开了一种热致变色微胶囊颜料，它由四种基本成分组成：(a) 一种电子供色有机化合物；(b) 一种电子受色化合物；(c) 一种决定成分(a)与成分(b)发生颜色反应的温度的反应介质；(d) 一种变色温度调节剂、变色温度调节剂(d)包括一种或多种从酯、醇、酮、酸酰胺、烃和脂肪酸组成的组中选出的化合物，其熔点 Y(℃)满足(X+30)℃≤Y≤200℃的关系，其中 X(℃)是组分(c)的熔点，四种基本组分被微胶囊化。