2-bromo-4,5,9,10-tetrahydropyrene | 10549-27-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 2-bromo-4,5,9,10-tetrahydropyrene
• 英文别名: 4,5,9,10-tetrahydro-2-bromopyrene；2-Brom-4,5,9,10-tetrahydro-pyren
• CAS: 10549-27-6
• 化学式: C₁₆H₁₃Br
• 分子量: 285.183
• InChiKey: SHWCNQXPUNDABM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-bromo-4,5,9,10-tetrahydropyrene 在 邻四氯苯醌 作用下， 以 苯 为溶剂， 反应 24.0h， 生成 trimethyl(2-pyren-1-ylethynyl)silane
  参考文献：
  名称：

  芳基乙炔是细胞色素P450依赖的单加氧酶的基于机理的抑制剂。

  摘要：

  已经研究了芳基乙炔在从暴露于β-萘黄酮，异黄酮或苯巴比妥的大鼠制备的肝微粒体中作为细胞色素P450（P450）依赖性烷氧基间苯二酚脱烷基化脱烷基活性的抑制剂。研究的许多乙炔会产生假一阶时间依赖性和NADPH依赖性的脱烷基活性损失，这些是基于机制的不可逆失活（自杀抑制）的特征。用甲基取代芳基乙炔的末端氢以将乙炔转化为丙炔，可以增强对P450 1A酶的抑制作用。在某些情况下，这种修饰将可逆的P450抑制剂转化为自杀抑制剂。相反，乙炔比相应的丙炔更有效地抑制P450 2B依赖性脱烷基的自杀。在大鼠肝微粒体内，在萘2位或菲9位上具有乙炔基的芳基乙炔和具有2、3或4个亚甲基烷基链的芳基烷基乙炔是P450 2B1 / 2B2的选择性抑制剂。芳基乙炔还充当人肝微粒体中P450 1A2的自杀抑制剂，重组系统中来自兔或大鼠肝脏的纯化P450 1A2的自杀抑制剂以及重组系统中纯化的重组人P450 1A2和1A

  DOI：

  10.1021/tx960064g
• 作为产物：
  描述：

  [2.2]Metacyclophan 在 溴 、 碘 作用下， 以 四氯化碳 为溶剂， 反应 1.0h， 以90%的产率得到2-bromo-4,5,9,10-tetrahydropyrene
  参考文献：
  名称：

  Wahl, Peter; Krieger, Claus; Schweitzer, Dieter, Chemische Berichte, 1984, vol. 117, # 1, p. 260 - 276

  摘要：

  DOI：

文献信息

• ANTHRACENE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT DEVICES MADE BY USING THE SAME
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：EP1533289A1

  公开（公告）日：2005-05-25

  An anthracene derivative represented by the following general formula (1) which enables an organic electroluminescence device to exhibit a great efficiency of light emission and uniform light emission even at high temperatures since crystallization is suppressed and no thermal decomposition takes place during vapor deposition and an organic electroluminescence device utilizing the derivative, are provided. [Ar represents a group represented by the following general formula (2): (L1 and L2 each represent a substituted or unsubstituted methylene group, ethylene group or the like, and at least one of them is present), Ar' represents a substituted or unsubstituted aryl group having 6 to 50 nuclear carbon atoms, X represent an alkyl group or the like, a and b each represent an integer of 0 to 4, and n represents an integer of 1 to 3.]

  本发明提供了由以下通式(1)表示的蒽衍生物和利用该衍生物的有机电致发光器件，前者由于在气相沉积过程中结晶被抑制且不发生热分解，因此即使在高温下也能表现出很高的发光效率和均匀的发光。 [Ar 代表由以下通式（2）表示的基团： (L1和L2各自代表取代或未取代的亚甲基、乙烯基或类似基团，且至少存在其中一个），Ar'代表具有6至50个核碳原子的取代或未取代的芳基，X代表烷基或类似基团，a和b各自代表0至4的整数，n代表1至3的整数]。
• Anthracene derivatives and organic electroluminescent devices made by using the same
  申请人：Ido Motohisa

  公开号：US20050233165A1

  公开（公告）日：2005-10-20

  An anthracene derivative represented by the following general formula (1) which enables an organic electroluminescence device to exhibit a great efficiency of light emission and uniform light emission even at high temperatures since crystallization is suppressed and no thermal decomposition takes place during vapor deposition and an organic electroluminescence device utilizing the derivative, are provided. [Ar represents a group represented by the following general formula (2): (L 1 and L 2 each represent a substituted or unsubstituted methylene group, ethylene group or the like, and at least one of them is present), Ar′ represents a substituted or unsubstituted aryl group having 6 to 50 nuclear carbon atoms, X represent an alkyl group or the like, a and b each represent an integer of 0 to 4, and n represents an integer of 1 to 3.]

  本发明提供了由以下通式(1)表示的蒽衍生物和利用该衍生物的有机电致发光器件，前者由于在气相沉积过程中结晶被抑制且不发生热分解，因此即使在高温下也能表现出很高的发光效率和均匀的发光。 [Ar 代表由以下通式（2）表示的基团： (L 1 和 L 2 分别代表取代或未取代的亚甲基、亚乙基或类似基团，且至少存在其中之一），Ar′代表具有 6 至 50 个核碳原子的取代或未取代的芳基，X 代表烷基或类似基团，a 和 b 分别代表 0 至 4 的整数，n 代表 1 至 3 的整数。］
• Medium-sized cyclophanes. 2. Bromination of 8-methoxy[2.2]metacyclophanes
  作者：Takehiko Yamato、Seiji Ide、Kiwamu Tokuhisa、Masashi Tashiro

  DOI：10.1021/jo00027a048

  日期：1992.1

  When 8-methoxy[2.2]metacyclophanes 5 are treated with benzyl trimethylammonium tribromide in dichloromethane, the transannular reaction products, tetrahydropyrene 6 and 7 are obtained along with 5-bromo-8-methoxy[2.2]metacyclophanes 8. The bromination of 5-tert-butyl-8-methoxy[2.2]metacyclophanes 9a-9g in dichloromethane is carried out under the same conditions to afford tetrahydropyrene derivatives exclusively. On the other hand, when the bromination reactions are performed in various alcohols, alkoxy-substituted tetrahydropyrenes 11 and 12 are obtained in good yields, which are easily dehydrogenated with DDQ to afford the corresponding pyrene derivatives. The reaction mechanisms of the above reactions are also discussed.
• EP1533289
  申请人：——

  公开号：——

  公开（公告）日：——
• Some chemistry of compounds related to [2.2]metacyclophane
  作者：Norman L. Allinger、Berner J. Gorden、Shih-En Hu、Richard A. Ford

  DOI：10.1021/jo01282a040

  日期：1967.7