5-Oxo-4-phenyl-capronsaeure-nitril | 19842-18-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Oxo-4-phenyl-capronsaeure-nitril
• 英文别名: 5-Cyano-3-phenyl-2-pentanone；5-oxo-4-phenylhexanenitrile
• CAS: 19842-18-3
• 化学式: C₁₂H₁₃NO
• 分子量: 187.241
• InChiKey: NQULVRFEVUXZQS-UHFFFAOYSA-N

物化性质

• 沸点：
  124-126 °C(Press: 0.01 Torr)
• 密度：
  1.053 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-Oxo-4-phenyl-capronsaeure-nitril 在 镍 potassium permanganate 、 palladium on activated charcoal 、 氢气 作用下， 以 乙醇 为溶剂， 80.0~310.0 ℃ 、9.65 MPa 条件下， 反应 8.5h， 生成 3-苯基-2-吡啶甲酸
  参考文献：
  名称：

  Pillai; Nand, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1990, vol. 29, # 9, p. 892 - 894

  摘要：

  DOI：
• 作为产物：
  描述：

  丙烯腈 、 苯基丙酮 在 sodium 作用下， 生成 5-Oxo-4-phenyl-capronsaeure-nitril
  参考文献：
  名称：

  1-Benzoyl-3-(arylphyridyl)urea compounds

  摘要：

  本发明涉及作为杀虫剂有用的1-苯甲酰基-3-(芳基吡啶基)脲化合物。

  公开号：

  US04405552A1

文献信息

• Chiral isoxazolidine-mediated stereoselective umpolung α-phenylation of methyl ketones
  作者：Norihiko Takeda、Mizuki Furuishi、Yuri Nishijima、Erika Futaki、Masafumi Ueda、Tetsuro Shinada、Okiko Miyata

  DOI：10.1039/c8ob02480d

  日期：——

  An effective asymmetric α-phenylation of methyl ketones with triphenylaluminium in the presence of (+)-benzopyranoisoxazolidine has been developed. The reaction proceeds via the in situ formation of a chiral N-alkoxyenamine and the subsequent diastereoselective nucleophilic phenylation to provide α-phenylated products in moderate to good yields, with high enantioselectivities.

  已经开发出在（+）-苯并吡喃并恶恶唑烷存在下，有效的甲基酮与三苯基铝的不​​对称α-苯基化反应。反应的进行通过所述原位形成手性的Ñ -alkoxyenamine和随后的非对映选择性亲核苯基化，以提供α-苯基化产品在中度至良好的产率，具有高对映选择性。
• Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose
  申请人：Alcon Laboratories, Inc.

  公开号：US05153211A1

  公开（公告）日：1992-10-06

  Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome. A particularly preferred class of compounds comprise difluoro-dialkoxy substituted spiro-(9H-fluorene-9,4'-imidazolidine)-2',5-diones.

  本发明涉及取代或未取代的平面三环芴或其核类似物，与含有次级酰胺的五元环螺合，以及其药学上可接受的盐。这些化合物在糖尿病的治疗中有用。本发明还涉及制备这些化合物的方法；包含这些化合物的制药组合物；以及在适用于糖尿病综合症的长期预防性治疗等情况下，通过给予这些化合物和组合物进行治疗的方法。一种特别优选的化合物类别包括二氟二烷氧基取代的螺-(9H-芴-9,4'-咪唑啉)-2',5-二酮。
• Spiro-tricyclicaromatic succinimide derivatives
  申请人：Alcon Laboratories, Inc.

  公开号：US05070100A1

  公开（公告）日：1991-12-03

  Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome. A particularly preferred class of compounds comprise difluoro-dialkoxy substituted spiro-(9H-fluorene-9,4'-imidazolidine)-2,40 ,5-diones.

  本发明涉及取代或未取代的平面三环芴或其核类似物，与含有二级酰胺的五元环螺合的化合物以及其药学上可接受的盐。这些化合物可用于治疗糖尿病等疾病。本发明还涉及制备这些化合物的方法；包含这些化合物的制药组合物；以及在适当时用于长期预防性治疗糖尿病综合症等情况下，通过给予这些化合物和组合物的治疗方法。其中一类特别优选的化合物包括二氟二烷氧基取代的螺-(9H-芴-9,4'-咪唑啉)-2,4,5-二酮。
• Process for the preparation of C-substituted pyridines and/or hydrogenated C-substituted pyridines
  申请人：STAMICARBON B.V.

  公开号：EP0009289A1

  公开（公告）日：1980-04-02

  An improved process for the preparation of pyridines and/or hydrogenated pyridines that have been substituted with a hydrocarbon group at one or mor carbon atoms. y-cyanoketone, in a gaseous phase and in the presence of hydrogen, is passed in a reaction zone over a first catalyst containing a catalytically active metal or compound of a metal selected from the group copper, silver, gold, iron, nickel, cobalt, ruthenium, rhodium, palladium, osmium, iridium and platinum to form a reaction mixture. A hydrogen-containing gas is separated from the reaction mixture, passed over a second catalyst containing a catalytically active metal or compound of a metal selected from the group iron, nickel and cobalt at a temperature of between 300 and 800°C, and the hydrogen-containing gas so treated is recycled to the reaction zone.

  一种制备吡啶和/或在一个或多个碳原子上被烃基取代的氢化吡啶的改进工艺。在气相和氢气存在的情况下，y-氰基酮在反应区通过第一催化剂，该第一催化剂含有催化活性金属或选自铜、银、金、铁、镍、钴、钌、铑、钯、锇、铱和铂的金属化合物，以形成反应混合物。 从反应混合物中分离出含氢气体，在300至800℃的温度下通过第二催化剂，该第二催化剂含有催化活性金属或选自铁、镍和钴的金属化合物，经如此处理的含氢气体再循环到反应区。
• Bertocchio,R.; Dreux,J., Bulletin de la Societe Chimique de France, 1962, p. 1809 - 1813
  作者：Bertocchio,R.、Dreux,J.

  DOI：——

  日期：——