氯-(4-甲基苯基)磺酰基亚胺钠 | 144-86-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氯-(4-甲基苯基)磺酰基亚胺钠
• 中文别名: N-氯对甲苯磺酰胺
• 英文名称: N-chloro-4-methylbenzenesulfonamide
• 英文别名: chloramine-T；N-chloro tosylamide；N-Chloro-p-toluenesulfonamide
• CAS: 144-86-5
• 化学式: C₇H₈ClNO₂S
• mdl: MFCD06661254
• 分子量: 205.665
• InChiKey: NXTVQNIVUKXOIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  氯-(4-甲基苯基)磺酰基亚胺钠 在 吡啶 、 四氧化锇 、 苄基三乙基氯化铵 作用下， 以 氯仿 、 水 、 叔丁醇 为溶剂， 反应 20.0h， 生成 DL-(1,3,4/2,6)-3-O-Acetyl-1,2-di-O-benzyl-6-benzyloxymethyl-4-p-toluenesulfonamido-1,2,3-cyclohexanetriol
  参考文献：
  名称：

  海藻糖，[（1S）-（（1,2,43,5）-2-amino-3,4-dihydroxy-5-hydroxymethyl-1-cyclohexyl]α-d-吡喃葡萄糖苷的碳糖类似物的合成，以及β端基异构体的修订合成

  摘要：

  α-D-葡萄糖苷的合成是通过将新制备的3,4,7-三-O-苄基-2-脱氧-2-对甲苯磺酰氨基-5a-卡巴-α-DL-吡喃葡萄糖与1缩合而进行的在三甲基甲硅烷基三氟甲磺酸酯存在下的6-二-O-乙酰基-2,3,4-三-O-苄基-β-D-吡喃葡萄糖2

  DOI：

  10.1016/0008-6215(90)80074-d
• 作为产物：
  描述：

  chloroamine-T 在 水 作用下， 生成 氯-(4-甲基苯基)磺酰基亚胺钠
  参考文献：
  名称：

  Mechanistic Investigation of Osmium(VIII) Catalyzed Oxidation of Glutamic Acid With Sodium Salt of N-Chloro 4-Methylbenzenesulfonamide in Aqueous Media: A Practical Approach

  摘要：

  L-glutamic acid is used in the production of monosodium glutamate spices and other biochemical reagents. Its oxidation kinetics and a detailed mechanistic interaction of Os(VIII) catalyzed Glue-CAT reaction in alkaline medium have been investigated at different temperatures. It has been studied spectrophotometrically as a basic experimental approach for this study. All variables affecting the development of the color were investigated and the conditions were optimized. The effect of Glue, CAT, Os(VIII), and OH concentration on the rate of reaction has been studied. The reactions follow identical kinetics for all It is a first order reaction in both Glue and CAT, but fractional order in alkali and Os(VIII). Increasing ionic strength dielectric constant of the medium had no significant effect on the rate. The effects of added products like halide ions and toluene-p-sulfonamide have also been investigated. A mechanism involving the formation of a complex between Glue-CAT-Os(VIII) has been proposed. The stoichiometry of the reaction is found to be 1:1. The main products of Glue were identified with the help of FTIR and TLC. The reaction constants involved in the mechanism are explained. There is a good agreement between the observed and calculated rate constants under different experimental conditions. Investigations at different temperatures allowed the determination of the activation parameters with respect to the slow step of the proposed mechanism. The proposed methods were successfully applied for the high yield of the products and short reaction times. It is also an inexpensive, simple, and smooth method.

  DOI：

  10.1080/15533174.2013.872141
• 作为试剂：
  描述：

  苯硫酚 在 sodium azide 、 氯-(4-甲基苯基)磺酰基亚胺钠 、 四丁基氯化铵 、 水 作用下， 以 乙腈 为溶剂， 反应 1.5h， 生成 苯磺酰基叠氮化物
  参考文献：
  名称：

  使用氯胺-T从硫醇一锅法合成磺酰胺和磺酰叠氮

  摘要：

  描述了由硫醇方便地合成磺酰胺和磺酰叠氮化物。通过用氯胺-T（= N-氯代甲苯磺酰胺= N-氯--4-甲基苯磺酰胺），四丁基氯化铵（Bu 4 NCl）和H 2 O氧化，可以完成从硫醇中磺酰氯的原位制备。在同一锅中与过量的胺或NaN 3反应。

  DOI：

  10.1002/hlca.201200648

文献信息

• Novel triterpene derivatives
  申请人：onepharm Research & Development GmbH

  公开号：EP2228380A1

  公开（公告）日：2010-09-15

  The present invention encompasses novel triterpene compounds of general formula I wherein R3a R3b R11a R11b R31 and R32 are defined as in claim 1, which are suitable for the prevention and/or treatment of diseases mediated by 11β-HSD and the use thereof for preparing a medicament having the above-mentioned properties.

  本发明涵盖了一般式I的新型三萜化合物， 其中 R3a、R3b、R11a、R11b、R31和R32如权利要求1所定义，适用于预防和/或治疗由11β-HSD介导的疾病，并用于制备具有上述特性的药物。
• [EN] ANTIVIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014135471A1

  公开（公告）日：2014-09-12

  The present invention discloses compounds of Formula (I): wherein the variables in Formula (I) are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula (I) in the prevention or treatment of HCV infection.

  本发明公开了化合物的结构式（I）：其中式（I）中的变量如本文所述。还公开了含有这种化合物的药物组合物，以及使用式（I）中的化合物预防或治疗HCV感染的方法。
• ENZYME-CATALYZED ENANTIOSELECTIVE AZIRIDINATION OF OLEFINS
  申请人：California Institute of Technology

  公开号：US20160222423A1

  公开（公告）日：2016-08-04

  The present invention provides methods for catalyzing the conversion of an olefin to a compound containing one or more aziridine functional groups using heme enzymes. In certain aspects, the present invention provides a reaction mixture for producing an aziridination product, the reaction mixture comprising of an olefinic substrate, a nitrene precursor, and a heme enzyme. In other certain aspects, the present invention provides a method for producing an aziridination product comprising providing an olefinic substrate, a nitrene precursor, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce an aziridine product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin aziridination reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.

  本发明提供了利用血红素酶催化烯烃转化为含有一个或多个氮杂环丙烷官能团的化合物的方法。在某些方面，本发明提供了用于生产氮杂环丙烷产物的反应混合物，该反应混合物包括烯烃底物、氮烯前体和血红素酶。在其他某些方面，本发明提供了一种生产氮杂环丙烷产物的方法，包括提供烯烃底物、氮烯前体和血红素酶；并将这些组分混合在反应中，以产生氮杂环丙烷产物所需的时间。在其他方面，本发明提供了包括能够在体内和体外进行烯烃氮杂环丙烷化反应的血红素酶及其变体和片段。本发明还提供了表达载体和表达血红素酶的宿主细胞。
• Kappa agonist compounds and pharmaceutical formulations thereof
  申请人：——

  公开号：US20030144272A1

  公开（公告）日：2003-07-31

  Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, IIA, III, IIIA, IIIB, IIIB-i, IV and IVA have the structure: 1 2 wherein R 1 , R 2 , R 3 , R 4 ; and X, X 4 , X 5 , X 7 , X 9 ; Y, Z and n are as described in the specification.

  提供具有kappa阿片受体激动剂活性的化合物，含有这些化合物的组合物以及使用它们作为镇痛剂的方法。 具有以下结构的化合物I、II、IIA、III、IIIA、IIIB、IIIB-i、IV和IVA： 1 2 其中 R 1 ，R 2 ，R 3 ，R 4 ；和 X，X 4 ，X 5 ，X 7 ，X 9 ； Y，Z和n如规范中所述。
• [EN] AMINO PYRAZINE DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS<br/>[FR] DÉRIVÉS AMINÉS DE PYRAZINE UTILISABLES EN TANT QU'INHIBITEURS DE LA PHOSPHATIDYLINOSITOL 3-KINASE
  申请人：NOVARTIS AG

  公开号：WO2015162459A1

  公开（公告）日：2015-10-29

  The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

  本发明提供了一种公式（I）的化合物，该化合物抑制PI 3-激酶γ同工酶的活性，对于治疗由PI 3-激酶γ同工酶激活介导的疾病是有用的。