N-[2-(4-Bromo-phenyl)-ethyl]-2,2-dimethyl-propionamide | 304664-18-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-(4-Bromo-phenyl)-ethyl]-2,2-dimethyl-propionamide
• 英文别名: N-[2-(4-bromophenyl)ethyl]-2,2-dimethylpropanamide
• CAS: 304664-18-4
• 化学式: C₁₃H₁₈BrNO
• mdl: MFCD01325789
• 分子量: 284.196
• InChiKey: RFSVCAULYXKUNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-[2-(4-Bromo-phenyl)-ethyl]-2,2-dimethyl-propionamide 在 palladium diacetate 、 正丁基锂 、 草酰氯 、 三氯化铁 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 乙醚 、 氯仿 为溶剂， 生成
  参考文献：
  名称：

  Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties

  摘要：

  A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.10.026
• 作为产物：
  描述：

  4-溴苯乙胺 、 三甲基乙酰氯 在 三乙胺 作用下， 生成 N-[2-(4-Bromo-phenyl)-ethyl]-2,2-dimethyl-propionamide
  参考文献：
  名称：

  Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties

  摘要：

  A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.10.026

文献信息

• NOVEL COMPOUND WITH ANTIBACTERIAL ACTIVITY
  申请人：JUNTENDO EDUCATIONAL FOUNDATION

  公开号：US20160257651A1

  公开（公告）日：2016-09-08

  A compound represented by the general formula (I) or a salt thereof having a potent antibacterial activity against bacteria that have acquired resistance to quinolones, and a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing the compound or a salt thereof as an active ingredient, as well as a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing a combination of the compound or a salt thereof, and a quinolone.

  一种由通式（I）表示的化合物或其盐，具有对已获得对喹诺酮抗性的细菌具有强效的抗菌活性，以及一种用该化合物或其盐作为活性成分的预防和/或治疗感染性疾病的药物，以及一种包含该化合物或其盐与喹诺酮的组合物作为活性成分的预防和/或治疗感染性疾病的药物。
• Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties
  作者：Milan Bruncko、William J. McClellan、Michael D. Wendt、Daryl R. Sauer、Andrew Geyer、Christopher R. Dalton、Michele A. Kaminski、Moshe Weitzberg、Jane Gong、Joseph F. Dellaria、Robert Mantei、Xumiao Zhao、Vicki L. Nienaber、Kent Stewart、Vered Klinghofer、Jennifer Bouska、Todd W. Rockway、Vincent L. Giranda

  DOI：10.1016/j.bmcl.2004.10.026

  日期：2005.1

  A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors. (C) 2004 Elsevier Ltd. All rights reserved.