9,9'-(1,3-phenylene)bis(2,2,7,7-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8-(2H)-dione) | 1259284-67-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 9,9'-(1,3-phenylene)bis(2,2,7,7-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8-(2H)-dione)
• 英文别名: 2,2,7,7-tetramethyl-9-[3-(2,2,7,7-tetramethyl-1,8-dioxo-4,5,6,9-tetrahydro-3H-xanthen-9-yl)phenyl]-4,5,6,9-tetrahydro-3H-xanthene-1,8-dione
• CAS: 1259284-67-7
• 化学式: C₄₀H₄₆O₆
• 分子量: 622.802
• InChiKey: QTHUEIJRQIDKGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  46
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  间苯二甲醛 、 4,4-二甲基-1,3-环己二酮 在 4-十二烷基苯磺酸 作用下， 以 水 为溶剂， 反应 2.5h， 以75%的产率得到9,9'-(1,3-phenylene)bis(2,2,7,7-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8-(2H)-dione)
  参考文献：
  名称：

  Synthesis and antimicrobial activity of some bisoctahydroxanthene-1,8-dione derivatives

  摘要：

  The bisoctahydroxanthen-1,8-dione derivatives were synthesized effectively via p-dodecylbenzene sulfonic acid the catalysed cyclocondensation of cyclic 1,3-dicarbonyl compounds with 1,3- or 1,4-benzene dicarboxaldehydes in water. The products were obtained with yield ranged from 75 to 95%. The structures of compounds were characterized by FT-IR, H-1-NMR and elemental analysis. The antimicrobial properties of compounds against pathogens were investigated by the disc-diffusion method. These compounds were evaluated for potential antimicrobial activity against Gram-positive (Staphylococcus aureus, Bacillus cereus, S. epidermidis and Nocardia canis), Gram-negative bacteria (Escherichia coli, Proteus vulgaris and Pseudomonas aeroginosa), yeasts (Candida albicans and Rhodotorula rubra) and mold (Aspergillus niger). The growth of S. aureus, B. cereus, S. epidermidis, E. coli, C. albicans, R. rubra and A. niger were inhibited by 3f and 3g compounds. All compounds were resistant against Gram-negative bacteria (Proteus vulgaris and Pseudomonas aerginosa) and results were upon comparison with reference discs.

  DOI：

  10.1007/s00044-010-9459-2

文献信息

• Synthesis and antimicrobial activity of some bisoctahydroxanthene-1,8-dione derivatives
  作者：Muharrem Kaya、Erhan Basar、Ferdağ Colak

  DOI：10.1007/s00044-010-9459-2

  日期：2011.11

  The bisoctahydroxanthen-1,8-dione derivatives were synthesized effectively via p-dodecylbenzene sulfonic acid the catalysed cyclocondensation of cyclic 1,3-dicarbonyl compounds with 1,3- or 1,4-benzene dicarboxaldehydes in water. The products were obtained with yield ranged from 75 to 95%. The structures of compounds were characterized by FT-IR, H-1-NMR and elemental analysis. The antimicrobial properties of compounds against pathogens were investigated by the disc-diffusion method. These compounds were evaluated for potential antimicrobial activity against Gram-positive (Staphylococcus aureus, Bacillus cereus, S. epidermidis and Nocardia canis), Gram-negative bacteria (Escherichia coli, Proteus vulgaris and Pseudomonas aeroginosa), yeasts (Candida albicans and Rhodotorula rubra) and mold (Aspergillus niger). The growth of S. aureus, B. cereus, S. epidermidis, E. coli, C. albicans, R. rubra and A. niger were inhibited by 3f and 3g compounds. All compounds were resistant against Gram-negative bacteria (Proteus vulgaris and Pseudomonas aerginosa) and results were upon comparison with reference discs.