2-(Azocan-4-yloxy)-5-phenyl-1,3,4-thiadiazole;methane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(Azocan-4-yloxy)-5-phenyl-1,3,4-thiadiazole;methane
• 英文别名: 2-(azocan-4-yloxy)-5-phenyl-1,3,4-thiadiazole;methane
• 化学式: C17H27N3OS
• 分子量: 321.5
• InChiKey: IZTKUTYQGUXPRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.39
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  75.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] AGONISTS OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR A7 SUBTYPE FOR USE IN THE TREATMENT OF COGNITIVE SYMPTOMS OF SCHIZOPHRENIA<br/>[FR] AGONISTES DU SOUS-TYPE A7 DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE NEURONAUX UTILISABLES DANS LE TRAITEMENT DE TROUBLES COGNITIFS DE LA SCHIZOPHRÉNIE
  申请人：ABBVIE INC

  公开号：WO2013177494A1

  公开（公告）日：2013-11-28

  The present invention relates to a pharmaceutical composition for use in the treatment of cognitive symptoms of schizophrenia comprising administering a therapeutically effective amount of a selective agonist of neuronal nicotinic acetylcholine receptor a7 subtype and a pharmaceutically acceptable. The selective agonist of neuronal nicotinic acetylcholine receptor a7 subtype is preferably (4s)-4-(5- 3 7 phenyl-l,3,4-thiadiazol-2-yloxy)-l- azatricyclo[3.3.1.13,7 ]decane, N- [2-(pyridin-3-ylmethyl)-l-azabicyclo[2.2.2]oct-3-yl]-l- benzofuran-2- carboxamide, N-[(3R)-l-azabicyclo[2.2.2]oct-3-yl]-7-chloro-l- benzothiophene-2-carboxamide, (R)-7-chloro-N-(quinuclidin-3-yl) benzo[b]thiophene-2- carboxamide or a salt thereof.