(4S,6R)-6-[(2S,4R,5S)-3-acetamido-2-[(3S,4R,6R)-6-[(3S,4R,6S)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-methyloxan-4-yl]oxy-4,5-dihydroxy-2-[[3-(methyldisulfanyl)propanoylamino]methylcarbamoyl]oxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-5-hydroxy-4-methoxyoxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4S,6R)-6-[(2S,4R,5S)-3-acetamido-2-[(3S,4R,6R)-6-[(3S,4R,6S)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-methyloxan-4-yl]oxy-4,5-dihydroxy-2-[[3-(methyldisulfanyl)propanoylamino]methylcarbamoyl]oxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-5-hydroxy-4-methoxyoxane-2-carboxylic acid
• 化学式: C₃₅H₅₈N₄O₂₁S₂
• 分子量: 935.0
• InChiKey: NAFRQTPBDBSEPN-AAZNHFCYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.7
• 重原子数：
  62
• 可旋转键数：
  19
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  420
• 氢给体数：
  12
• 氢受体数：
  23

文献信息

• HYALURONIC ACID-NUCLEIC ACID CONJUGATE AND COMPOSITION FOR NUCLEIC ACID DELIVERY CONTAINING THE SAME
  申请人：POSTECH ACADEMY-INDUSTRY FOUNDATION

  公开号：US20140080897A1

  公开（公告）日：2014-03-20

  The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of nucleic acid delivery system using the same. Specifically, a hyaluronic acid-nucleic acid complex wherein a hyaluronic acid-alkylenediamine conjugate and nucleic acid are connected by a disulfide bond; a composition for nucleic acid delivery comprising the hyaluronic acid-nucleic acid complex as an active ingredient; a method for preparing the hyaluronic acid-nucleic acid complex; and a method for in vivo delivery of nucleic acid, comprising administering the hyaluronic acid-nucleic acid complex to a subject are provided.