(2S)-4-(2-aminoethylamino)-4-ethyl-2-(3-ethyl-2-oxopentan-3-yl)oxyhexan-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S)-4-(2-aminoethylamino)-4-ethyl-2-(3-ethyl-2-oxopentan-3-yl)oxyhexan-3-one
• 化学式: C₁₇H₃₄N₂O₃
• 分子量: 314.5
• InChiKey: JRAOUHBREWCMGT-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• BRANCHED AMPHIPATHIC BLOCK POLYMER AND MOLECULAR AGGREGATE AND DRUG DELIVERY SYSTEM USING SAME
  申请人：Ozeki Eiichi

  公开号：US20140127132A1

  公开（公告）日：2014-05-08

  Provided is a polymeric micelle pharmaceutical preparation that can increase the ratio of contrast at tumor site to background contrast in a short period of time after administration of a lactosome and can suppress the ABC phenomenon so that the lactosome can be administered more than once within a short span. A branched-type amphiphilic block polymer comprising: a multi-branched hydrophilic block comprising sarcosine; and a hydrophobic block comprising polylactic acid. The branched-type amphiphilic block polymer, wherein the number of branches of the hydrophilic block is 3. A molecular assembly comprising the branched-type amphiphilic block polymer. The molecular assembly further comprising a linear type amphiphilic block polymer.

  提供的是一种聚合物胶束制药制剂，可以在给予乳状体后的短时间内增加肿瘤部位与背景对比的比例，并且可以抑制ABC现象，使得乳状体可以在短时间内多次给药。包括以下部分的分支型两性块聚合物：包括硫氨酸的多支链亲水块；和包括聚乳酸的疏水块。该分支型两性块聚合物，其中亲水块的支链数为3。包括该分支型两性块聚合物的分子组装体。该分子组装体进一步包括线型两性块聚合物。
• NOVEL MOLECULAR ASSEMBLY, MOLECULAR PROBE FOR MOLECULAR IMAGING AND MOLECULAR PROBE FOR DRUG DELIVERY SYSTEM USING THE SAME, AND MOLECULAR IMAGING SYSTEM AND DRUG DELIVERY SYSTEM
  申请人：SHIMADZU CORPORATION

  公开号：US20190105412A1

  公开（公告）日：2019-04-11

  The present invention provides a molecular assembly which is less likely to accumulate in tissue other than cancer tissue, is highly safe for a living body, and can be prepared by a simple and safe method and whose particle size can be easily controlled. The present invention provides a molecular imaging system and a molecular probe useful for the system, and a drug delivery system and a molecular probe useful for the system. The present invention provides a method for preparing molecular assembly, by which the particle size of molecular assembly having a signal group or a drug can be arbitrarily controlled in order to allow the molecular assembly to effectively accumulate in cancer tissue by utilizing EPR effect. A molecular assembly comprising: an amphiphilic block polymer A comprising a hydrophilic block chain and a hydrophobic block chain having 10 or more lactic acid units; a hydrophobic polymer A2 having at least 10 or more lactic acid units; and/or a labeled polymer B comprising at least 10 or more lactic acid units and a labeling group.

  本发明提供了一种分子组装体，其不太可能在癌组织以外的组织中积累，对生物体高度安全，并且可以通过简单安全的方法制备，其粒子大小可以轻松控制。本发明提供了一种分子成像系统和用于该系统的分子探针，以及用于该系统的药物递送系统和分子探针。本发明提供了一种制备分子组装体的方法，通过该方法可以任意控制具有信号基团或药物的分子组装体的粒子大小，以利用EPR效应使分子组装体有效地积累在癌组织中。一种分子组装体，包括：一种含有10个或更多乳酸单元的亲水性块链和疏水性块链的两亲性块聚物A；一种含有至少10个或更多乳酸单元的疏水性聚合物A2；和/或一种标记聚合物B，包括至少10个或更多乳酸单元和一个标记基团。
• Manufacturing method for nanoparticle
  申请人：SHIMADZU CORPORATION

  公开号：US10035887B2

  公开（公告）日：2018-07-31

  A manufacturing method for nanoparticles including an amphiphilic block polymer having a uniform particle diameters has steps of forming a laminar flow of polymer solution by inducing a solution comprising an amphiphilic block polymer having a hydrophilic block and a hydrophobic block in an organic solvent into a polymer solution supply flow passage, a step of forming at least two laminar flows of a water system solution by inducing the water system solution to at least two water system solution supply passages, and a step of forming nanoparticles comprising the amphiphilic block polymer by making a confluence as if at least two laminar flows of water system solution sandwich the laminar flow of the polymer solution.

  一种包括具有均匀颗粒直径的两性嵌段聚合物的纳米颗粒的制造方法，其步骤包括：通过将在有机溶剂中具有亲水嵌段和疏水嵌段的两性嵌段聚合物组成的溶液引入聚合物溶液供应流道，形成聚合物溶液的层流、通过将水系统溶液引入至少两个水系统溶液供应流道，形成至少两股水系统溶液层流的步骤，以及通过使至少两股水系统溶液层流夹在聚合物溶液层流中形成汇流，形成包含两性嵌段聚合物的纳米颗粒的步骤。
• Medicinal agent-containing molecular assembly which uses amphiphilic block polymer
  申请人：SHIMADZU CORPORATION

  公开号：US11224578B2

  公开（公告）日：2022-01-18

  Provided is a molecular assembly (for example, a polymeric micelle nanoparticle) which is capable of efficiently encapsulating a fat-soluble drug. A molecular assembly comprising: an amphiphilic block polymer A1 comprising a hydrophilic block having a sarcosine unit and a hydrophobic block having a lactic acid unit; a hydrophobic polymer A2 having a lactic acid unit; a fatty acid triglyceride; and a fat-soluble drug. Examples of the fat-soluble drug include miriplatin.

  本发明提供了一种分子组件（例如聚合物胶束纳米粒子），它能够有效地封装脂溶性药物。分子组件包括：两亲性嵌段聚合物 A1，其中包括具有肌氨酸单元的亲水嵌段和具有乳酸单元的疏水嵌段；具有乳酸单元的疏水聚合物 A2；脂肪酸甘油三酯；以及脂溶性药物。脂溶性药物的例子包括米利铂。
• MOLECULAR ASSEMBLY USING AMPHIPATHIC BLOCK POLYMER, AND SUBSTANCE-CONVEYANCE CARRIER USING SAME
  申请人：SHIMADZU CORPORATION

  公开号：US20190151454A1

  公开（公告）日：2019-05-23

  Provided is a molecular assembly having any nano-sized particle diameter depending on its intended use and application, in various fields such as pharmaceutical drugs, agricultural, chemicals, cosmetics, food products, and electronics. Furthermore, provided is a nano-carrier for delivering various substances using the molecular assembly having any nano-sized particle diameter. A molecular assembly comprising: an amphiphilic block polymer A1 comprising a hydrophilic block having a sarcosine unit and a hydrophobic block having a lactic acid unit; and an amorphous hydrophobic polymer A2 having an aliphatic hydroxy acid unit, wherein a number of aliphatic hydroxy acid units contained in the amorphous hydrophobic polymer A2 exceeds twice a number of lactic acid units contained in the hydrophobic block of the amphiphilic block polymer A1.