[1-[(2R,3S,4R,5R)-5-(2-amino-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]-2-methylbutan-2-yl]oxy-(3-hydroxypentan-3-yl)phosphinic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [1-[(2R,3S,4R,5R)-5-(2-amino-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]-2-methylbutan-2-yl]oxy-(3-hydroxypentan-3-yl)phosphinic acid
• 化学式: C₂₀H₃₃N₄O₈P
• 分子量: 488.5
• InChiKey: RERCIGCVMRNVDE-RXUYWNQFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  189
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• MODIFIED POLYNUCLEOTIDES ENCODING SEPTIN-4
  申请人：Bancel Stephane

  公开号：US20140141067A1

  公开（公告）日：2014-05-22

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
• US20140255467A1
  申请人：——

  公开号：US20140255467A1

  公开（公告）日：2014-09-11
• METHODS OF INCREASING THE VIABILITY OR LONGEVITY OF AN ORGAN OR ORGAN EXPLANT
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20150051268A1

  公开（公告）日：2015-02-19

  The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules for their use in improving organ viability and/or longevity.
• MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF
  申请人：Moderna Therapeutics, Inc.

  公开号：US20170056528A1

  公开（公告）日：2017-03-02

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
• US9149506B2
  申请人：——

  公开号：US9149506B2

  公开（公告）日：2015-10-06