(6R,8R,8aS)-6-[[(6R,8R,8aS)-6-[[(6R,8R,8aS)-6-[[(6R,8R,8aS)-6-(5-azidopentoxy)-7-methyl-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl]oxy]-7-methyl-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl]oxy]-7-methyl-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl]oxy]-7-methyl-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (6R,8R,8aS)-6-[[(6R,8R,8aS)-6-[[(6R,8R,8aS)-6-[[(6R,8R,8aS)-6-(5-azidopentoxy)-7-methyl-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl]oxy]-7-methyl-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl]oxy]-7-methyl-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl]oxy]-7-methyl-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-ol
• 化学式: C61H75N3O17
• 分子量: 1122.3
• InChiKey: LKTULKRUCWFJSF-LHYURTTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  81
• 可旋转键数：
  17
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  182
• 氢给体数：
  1
• 氢受体数：
  19

文献信息

• TYROSINE LIGATION PROCESS
  申请人：Adamo Roberto

  公开号：US20140141034A1

  公开（公告）日：2014-05-22

  A process is provided for preparing a conjugate of Formula (I-A) or (I) comprising a polypeptide containing n number of tyrosine units, where n is an integer greater than or equal to 1, dispersed within the amino acid chain having and amino terminus end (A 1 ) and an acid terminus end (A 2 ) of the protein or polypeptide and having a weight average molecular weight equal to or greater than 10,000 Daltons (10 kDa), wherein the conjugate comprises a number m of tyrosine conjugates (modified tyrosine residues) as depicted in Formula (I-A) or (I), where m is at least one and is less than or equal to n: where X, Lg, L and R are as defined herein.

  提供了一种制备公式（I-A）或（I）的共轭物的方法，其中包含n个酪氨酸单元的多肽，其中n是大于或等于1的整数，分散在具有氨基端末（A1）和酸端末（A2）的氨基酸链中，并且具有平均分子量大于或等于10,000道尔顿（10 kDa）的蛋白质或多肽，其中共轭物包括如公式（I-A）或（I）所示的m个酪氨酸共轭物（修饰的酪氨酸残基），其中m至少为1且小于或等于n：其中X，Lg，L和R如此处所定义。
• US9149541B2
  申请人：——

  公开号：US9149541B2

  公开（公告）日：2015-10-06