N-[2-[hydroxy(methyl)amino]ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methylsulfinyloxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[2-[hydroxy(methyl)amino]ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methylsulfinyloxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide
• 化学式: C₃₁H₄₅N₃O₈S
• 分子量: 619.8
• InChiKey: IBHSXRKNJGAWSM-WHMCVLTCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  43
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  188
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• [EN] INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1<br/>[FR] INHIBITEURS DU COTRANSPORTEUR SODIUM GLUCOSE 1
  申请人：LEXICON PHARMACEUTICALS INC

  公开号：WO2014081660A1

  公开（公告）日：2014-05-30

  Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula (I): the various substituents of which are defined herein.

  抑制钠葡萄糖共转运蛋白1（SGLT1）的抑制剂，包含它们的组合物，以及它们用于治疗糖尿病等疾病和紊乱的方法被披露。特定化合物的结构式如下（I）：其中各种取代基在此处被定义。
• INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1
  申请人：LEXICON PHARMACEUTICALS, INC.

  公开号：US20160326205A1

  公开（公告）日：2016-11-10

  Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.

  本文披露了钠葡萄糖协同转运体1（SGLT1）的抑制剂，包括它们的组合物和使用它们治疗糖尿病等疾病和疾病的方法。具体化合物的公式为：其中各取代基在此被定义。