N'-[1-(dimethylamino)ethenyl]ethanimidamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N'-[1-(dimethylamino)ethenyl]ethanimidamide
• 化学式: C₆H₁₃N₃
• 分子量: 127.19
• InChiKey: HDCFBMWFOJHKJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] COMBINATIONS OF METFORMIN WITH OTHER COMPOUNDS FOR THE TREATMENT OF CANCER AND FOR IMMUNOSUPPRESSION<br/>[FR] COMBINAISONS DE METFORMINE AVEC D'AUTRES COMPOSÉS POUR LE TRAITEMENT DU CANCER ET POUR L'IMMUNOSUPPRESSION
  申请人：UNIV BASEL

  公开号：WO2014083095A1

  公开（公告）日：2014-06-05

  The invention relates to combinations of metformin or related biguanides such as phenformin, buformin or proguanil, with particular metformin sensitizing compounds that have the capability to sensitize rapidly proliferating cells to metformin or related biguanides in such a way that combinations cause cell lethality at concentrations where neither metformin alone nor such metformin sensitizing compounds alone exert appreciable cell lethality. The invention further relates to the use of such combinations in the treatment of cancer and for achieving immunosuppression.