(4S,5R)-6-(hydroxymethyl)-3-methyloxane-2,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4S,5R)-6-(hydroxymethyl)-3-methyloxane-2,4,5-triol
• 化学式: C₇H₁₄O₅
• 分子量: 178.18
• InChiKey: YVJXTNFYGMZWPR-YDHXXATLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• METHOD FOR IMAGING CELL USING FLUORESCENCE-LABELED SUGAR DERIVATIVE HAVING COUMARIN DERIVATIVE BOUND THERETO, AND IMAGING AGENT
  申请人：Hirosaki University

  公开号：US20150369797A1

  公开（公告）日：2015-12-24

  The present invention has an object of providing a sugar derivative emitting blue fluorescence color which can be used for imaging of cells or intracellular molecules and a method for imaging cells using the derivative. Further, the present invention has an object of providing a method for detecting cancer cells at high accuracy by imaging, and an imaging agent used for this method. The present invention provides a fluorescently labeled sugar derivative having 3-carboxy-6,8-difluoro-7-hydroxycoumarin or 3-carboxymethyl-6,8-difluoro-7-hydroxy-4-methylcoumarin as a fluorescent molecular group in its molecule, and a cell imaging agent and an imaging method using the derivative. Further, the present invention provides an imaging agent and an imaging method for cancer cells using an L-glucose derivative having the above-described fluorescent molecular group in its molecule.

  本发明旨在提供一种发出蓝色荧光颜色的糖衍生物，可用于细胞或细胞内分子的成像，以及使用该衍生物成像细胞的方法。此外，本发明旨在提供一种通过成像高精度检测癌细胞的方法，以及用于该方法的成像剂。本发明提供一种含有3-羧基-6,8-二氟-7-羟基香豆素或3-羧甲基-6,8-二氟-7-羟基-4-甲基香豆素作为其分子中的荧光分子基团的荧光标记糖衍生物，以及使用该衍生物的细胞成像剂和成像方法。此外，本发明提供一种使用具有上述荧光分子基团的L-葡萄糖衍生物的成像剂和成像方法，用于癌细胞。
• METHOD FOR DETECTING CANCER CELL USING FLUORESCENTLY LABELED L-GLUCOSE DERIVATIVE, AND CANCER CELL-IMAGING AGENT COMPRISING FLUORESCENTLY LABELED L-GLUCOSE DERIVATIVE
  申请人：Yamada Katsuya

  公开号：US20140154717A1

  公开（公告）日：2014-06-05

  The purpose of the present invention is to provide a method for highly accurately detecting a cancer cell. The method of the present invention is characterized by comprising imaging with the use of a fluorescently labeled L-glucose derivative. By using the method and imaging agent according to the present invention, a high contrast between a cancer cell and a normal cell can be obtained compared with the case that imaging is conducted with the use of a fluorescently labeled D-glucose derivative. According to this method, moreover, no fasting is needed for the determination. Thus, the imaging can be quickly carried out without imposing a burden on a patient.

  本发明的目的是提供一种高精度检测癌细胞的方法。本发明的方法的特点在于使用荧光标记的L-葡萄糖衍生物进行成像。通过使用本发明的方法和成像剂，与使用荧光标记的D-葡萄糖衍生物进行成像相比，可以获得癌细胞和正常细胞之间的高对比度。此外，根据本方法，不需要进行禁食以进行确定，因此可以在不对患者造成负担的情况下快速进行成像。
• NOVEL GLUCOSE DERIVATIVE, AND CELL IMAGING METHOD AND IMAGING AGENT USING SAID DERIVATIVE
  申请人：HIROSAKI UNIVERSITY

  公开号：US20170122955A1

  公开（公告）日：2017-05-04

  Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided are a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.