2-Amino-4-(2-amino-4-hydroxyphenyl)-3-hydroxy-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Amino-4-(2-amino-4-hydroxyphenyl)-3-hydroxy-4-oxobutanoic acid
• 英文别名: 2-amino-4-(2-amino-4-hydroxyphenyl)-3-hydroxy-4-oxobutanoic acid
• 化学式: C₁₀H₁₂N₂O₅
• 分子量: 240.21
• InChiKey: DNWGEALUJBFTEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  147
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• SOLOMONAMIDE ANALOGUE COMPOUNDS, PHARMACEUTICALS CONTAINING SOLOMONAMIDE ANALOGUE COMPOUNDS, AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US20150291659A1

  公开（公告）日：2015-10-15

  Solomanamide analogues of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogues, including the synthesis of macrocyclic core of Salomanamide analogues. The Solomanamide analogues of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.

  公式I的Solomanamide类似物具有抗炎活性，并且具有制备这种类似物的可行合成路线，包括制备Salomanamide类似物的大环核心的合成。公式I的Solomanamide类似物或其药物盐可以在药物组合物中提供，并以有效剂量用于治疗炎症和/或疼痛。
• A PROCESS FOR THE PREPARATION OF SOLOMONAMIDE ANALOGUES
  申请人：Council of Scientific & Industrial Research

  公开号：EP2925771B1

  公开（公告）日：2021-08-18
• US9751911B2
  申请人：——

  公开号：US9751911B2

  公开（公告）日：2017-09-05
• [EN] A PROCESS FOR THE PREPARATION OF SOLOMONAMIDE ANALOGUES<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ANALOGUES DU SOLOMONAMIDE
  申请人：COUNCIL OF SCIENT & IND RESERACH AN INDIAN REGISTERED BODY INC UNDER THE REGN OF SOC ACT ACT XXI OF

  公开号：WO2014083578A1

  公开（公告）日：2014-06-05

  The invention disclosed herein relates to novel solomonamide analogues of formula I having anti-inflammatory activity and viable synthetic route for the preparation thereof.