4-acetyl-N-[(E)-(3-acetylcyclopentylidene)amino]benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-acetyl-N-[(E)-(3-acetylcyclopentylidene)amino]benzenesulfonamide
• 化学式: C₁₅H₁₈N₂O₄S
• 分子量: 322.4
• InChiKey: SFJRGXZKOMWVNY-JQIJEIRASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] MACROMOLECULES OF DENDRIMER-PLATINUM CONJUGATES<br/>[FR] MACROMOLÉCULES DE CONJUGUÉS DENDRIMÈRE-PLATINE
  申请人：STARPHARMA PTY LTD

  公开号：WO2015035446A1

  公开（公告）日：2015-03-19

  The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least one platinum-containing moiety is attached. In particular embodiments, the macromolecule has a plurality of platinum-containing moieties attached to the surface amino groups. In another particular embodiment, the macromolecule comprises a dendrimer having surface amino groups to which at least two different moieties are attached, a first moiety being a platinum-containing moiety and the second moiety being a pharmacokinetic modifying agent or targeting agent. Pharmaceutical compositions comprising the macromolecules and uses of the macromolecules for treating or suppressing the growth of a cancer is also described.

  本发明涉及一种包括具有表面氨基团的树枝状分子的大分子，其中至少连接有一个含铂基团。在特定实施方式中，该大分子具有连接到表面氨基团的多个含铂基团。在另一特定实施方式中，该大分子包括具有表面氨基团的树枝状分子，其中至少连接有两种不同的基团，第一种基团是含铂基团，第二种基团是药代动力学改性剂或靶向剂。还描述了包括这些大分子的药物组合物以及这些大分子用于治疗或抑制癌症生长的用途。
• MACROMOLECULES OF DENDRIMER-PLATINUM CONJUGATES
  申请人：STARPHARMA PTY LTD.

  公开号：US20160220689A1

  公开（公告）日：2016-08-04

  A macromolecule comprising a dendrimer having surface amino groups to which at least one platinum-containing moiety is attached is provided. The macromolecule may have a plurality of platinum-containing moieties attached to the surface amino groups. Alternatively, the macromolecule may comprise a dendrimer having surface amino groups to which at least two different moieties are attached, a first moiety being a platinum-containing moiety and the second moiety being a pharmacokinetic modifying agent or targeting agent. Pharmaceutical compositions comprising the macromolecules and uses of the macromolecules for treating or suppressing the growth of a cancer is also described.

  本发明提供了一种大分子，包括具有表面氨基团的树状分子，至少一个含铂基团附着于其上。该大分子可以具有多个附着在表面氨基团上的含铂基团。或者，该大分子可以包括具有表面氨基团的树状分子，至少附着有两种不同的基团，第一种基团是含铂基团，第二种基团是药物动力学修饰剂或靶向剂。还描述了包括该大分子的制药组合物以及使用该大分子治疗或抑制癌症生长的用途。
• MACROMOLECULES
  申请人：Owen David

  公开号：US20140171375A1

  公开（公告）日：2014-06-19

  The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl group and being attached to the surface amino group of the dendrimer through a diacid linker. Pharmaceutical compositions comprising the macromolecules and methods of treatment using the macromolecules are also described.
• US9744246B2
  申请人：——

  公开号：US9744246B2

  公开（公告）日：2017-08-29