1-[2-(3-Cyano-4-methoxy-2-methylphenyl)-2-oxoethyl]-2-(hydroxymethyl)piperazine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-(3-Cyano-4-methoxy-2-methylphenyl)-2-oxoethyl]-2-(hydroxymethyl)piperazine-2-carboxylic acid
• 英文别名: 1-[2-(3-cyano-4-methoxy-2-methylphenyl)-2-oxoethyl]-2-(hydroxymethyl)piperazine-2-carboxylic acid
• 化学式: C₁₇H₂₁N₃O₅
• 分子量: 347.4
• InChiKey: TXOOIVIZTTWNNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  123
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2934533A2

  公开（公告）日：2015-10-28
• [EN] INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL<br/>[FR] INHIBITEURS DU CANAL POTASSIQUE MÉDULLAIRE EXTERNE RÉNAL
  申请人：MERCK SHARP & DOHME

  公开号：WO2014099633A2

  公开（公告）日：2014-06-26

  The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kirl.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.