1-(5-Fluoro-2-pyrimidin-2-ylphenyl)ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(5-Fluoro-2-pyrimidin-2-ylphenyl)ethanone
• 英文别名: 1-(5-fluoro-2-pyrimidin-2-ylphenyl)ethanone
• 化学式: C₁₂H₉FN₂O
• 分子量: 216.21
• InChiKey: JSKFNAUEPUCCRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 2-PYRIDYLOXY-3-ESTER-4-NITRILE OREXIN RECEPTOR ANTAGONISTS
  申请人：KUDUK Scott D.

  公开号：US20150252033A1

  公开（公告）日：2015-09-10

  The present invention is directed to 2-pyridyloxy-3-ester-4-nitrile compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-3-ester-4-nitrile compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及2-吡啶氧基-3-酯基-4-腈基化合物，其为促进睡眠激素受体的拮抗剂。本发明还涉及使用所述2-吡啶氧基-3-酯基-4-腈基化合物治疗或预防神经和精神障碍疾病，以及其中涉及促进睡眠激素受体的疾病。本发明还涉及包含这些化合物的制药组合物。本发明还涉及使用这些制药组合物预防或治疗涉及促进睡眠激素受体的疾病。
• PIPERIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONIST
  申请人：SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.

  公开号：US20170233385A1

  公开（公告）日：2017-08-17

  The present invention discloses a series of piperidine derivatives as orexin receptor antagonists and compositions thereof, and relates to the application thereof in preparing medications for the treatment of insomnia, chronic obstructive pulmonary disease, obstructive sleep apnea, hypersomnia, anxiety, obsessive-compulsive disorder, panic attack, nicotine addiction, or binge eating disorder.
• US9586950B2
  申请人：——

  公开号：US9586950B2

  公开（公告）日：2017-03-07
• US9765057B2
  申请人：——

  公开号：US9765057B2

  公开（公告）日：2017-09-19
• [EN] 3-ESTER-4-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DES RÉCEPTEURS DE L'OREXINE 3-ESTER-4-SUBSTITUÉS
  申请人：MERCK SHARP & DOHME

  公开号：WO2014099697A1

  公开（公告）日：2014-06-26

  The present invention is directed to 3-ester-4-substituted compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 3-ester-4-substituted compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.