methyl (2S,3S,4R,5S)-3,4,5-triacetyloxy-6-(2-oxopropyl)oxane-2-carboxylate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl (2S,3S,4R,5S)-3,4,5-triacetyloxy-6-(2-oxopropyl)oxane-2-carboxylate
• 化学式: C₁₆H₂₂O₁₀
• 分子量: 374.34
• InChiKey: XMDXMCLBBAKETD-CHZLEKFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  132
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• Methods of preparing antibody-active agent conjugates
  申请人：LegoChem Biosciences, Inc.

  公开号：US20140187756A1

  公开（公告）日：2014-07-03

  The invention provides methods for preparing an antibody-active agent conjugate. The conjugate comprises an antibody, a cysteine residue of an amino acid motif that can be recognized by an isoprenoid transferase located at or after the carboxy-terminus of the antibody, an isoprenoid unit operably linked to the cysteine residue, and an active agent. The invention also provides a composition comprising the antibody-active agent conjugate prepared by the methods.