4-amino-1-[(2R,3R,4S,5R)-5-amino-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-amino-1-[(2R,3R,4S,5R)-5-amino-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• 化学式: C₉H₁₄N₄O₅
• 分子量: 258.23
• InChiKey: KYPHCUPZZSZLPY-JVZYCSMKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  155
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• ALKYNYL NUCLEOSIDE ANALOGS AS INHIBITORS OF HUMAN RHINOVIRUS
  申请人：NOVARTIS AG

  公开号：US20170275329A1

  公开（公告）日：2017-09-28

  The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions for treatment of viral infections, especially HRV.

  本发明提供了化合物I式或其盐；以及这些化合物的治疗用途。该发明还提供了包括这些化合物的药物组合物，以及包括这些化合物与治疗辅助剂的组合物，并且提供了使用这些化合物和组合物治疗病毒感染，特别是HRV的方法。
• Stereoselective synthesis of phosphorus containing actives
  申请人：Gilead Pharmasset LLC

  公开号：EP2752422A1

  公开（公告）日：2014-07-09

  Disclosed herein is a process for preparing an enantiomerically- or a diastereomerically enriched phosphorus-containing active, salt, or pharmaceutically acceptable salt thereof, of formula I-1 , which comprises the steps of: (a) reacting a protected or unprotected Active with a base to form a salt of said active and then reacting said salt with an enantiomerically- or a diastereomerically enriched compound of formula II-1 wherein the Active is a nucleoside, a nucleoside-analog, or a non-nucleoside.

  本文公开了一种制备式 I-1 的对映体或非对映异构体富集的含磷活性物质、盐或其药学上可接受的盐的方法 ，其步骤包括(a) 使受保护或未受保护的活性物质与碱反应，形成所述活性物质的盐，然后使所述盐与富含对映体或非对映异构体的式 II-1 化合物反应； (b) 使受保护或未受保护的活性物质与碱反应，形成所述活性物质的盐，然后使所述盐与富含对映体或非对映异构体的式 II-1 化合物反应。 其中活性物质为核苷、核苷类似物或非核苷。
• Alkynyl nucleoside analogs as inhibitors of human rhinovirus
  申请人：NOVARTIS AG

  公开号：US10428105B2

  公开（公告）日：2019-10-01

  The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions for treatment of viral infections, especially HRV.

  本发明提供了一种式（I）化合物或其盐； 以及这些化合物的治疗用途。本发明进一步提供了包含这些化合物的药物组合物、包含这些化合物与治疗共用试剂的组合物，以及使用这些化合物和组合物治疗病毒感染（尤其是 HRV）的方法。
• SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
  申请人：Alios BioPharma, Inc.

  公开号：US20180079774A1

  公开（公告）日：2018-03-22

  Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a norovirus, with a nucleoside, a nucleotide and an analog thereof.
• US9815864B2
  申请人：——

  公开号：US9815864B2

  公开（公告）日：2017-11-14