acetic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: acetic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
• 化学式: C9H21NO7
• 分子量: 255.27
• InChiKey: ZWDNNHGBFZORAR-LJTMIZJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.27
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  151
• 氢给体数：
  7
• 氢受体数：
  8

文献信息

• COMPOUNDS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH DGAT1 ACTIVITY
  申请人：CAPACCI-DANIEL Christina

  公开号：US20140200246A1

  公开（公告）日：2014-07-17

  The present invention relates to novel crystalline forms of salts of 2-((1R,4R)-4-(4-(5-(benzo[d]oxazol-2-ylamino)pyridin-2-yl)phenyl)cyclohexyl)acetic acid and their use in the treatment or prevention of a condition or a disorder associated with DGAT1 activity in animals, particularly humans.

  本发明涉及2-((1R,4R)-4-(4-(5-(苯并[d]噁唑-2-基氨基)吡啶-2-基)苯基)环己基)乙酸盐的新晶型及其在治疗或预防与动物（尤其是人类）DGAT1活性相关的疾病或疾病中的应用。
• BBB-PASSING LIPID LIGAND OF HETERO NUCLEIC ACID
  申请人：National University Corporation Tokyo Medical and Dental University

  公开号：EP3770257A1

  公开（公告）日：2021-01-27

  The object of the present invention is to provide a nucleic acid agent that can be efficiently delivered to the nervous system, particularly the central nervous system to which the BBB mechanism prevents drug delivery, and can produce an antisense effect on a target transcriptional product at the delivered site, and a composition comprising the same. Provided is a double-stranded nucleic acid complex formed by annealing a first nucleic acid strand capable of hybridizing to part of a target transcriptional product, and has an antisense effect on the target transcriptional product, to a second nucleic acid strand comprising a base sequence complementary to the first nucleic acid strand, and is bound to tocopherol or an analog thereof, cholesterol or an analog thereof, or a substituted or unsubstituted C1-30 alkyl group, a substituted or unsubstituted C2-30 alkenyl group, or a substituted or unsubstituted C1-30 alkoxy group.

  本发明的目的是提供一种核酸制剂，它可以有效地递送到神经系统，特别是BBB机制阻碍药物递送的中枢神经系统，并能在递送部位对靶转录产物产生反义效应，以及包含该制剂的组合物。 本发明提供了一种双链核酸复合物，该复合物通过将能够与目标转录产物的一部分杂交的第一核酸链与包含与第一核酸链互补的碱基序列的第二核酸链退火形成，并对目标转录产物具有反义作用、并与生育酚或其类似物、胆固醇或其类似物、或取代或未取代的 C1-30 烷基、取代或未取代的 C2-30 烯基、或取代或未取代的 C1-30 烷氧基结合。
• EP3766972A1
  申请人：——

  公开号：EP3766972A1

  公开（公告）日：2021-01-20
• NUCLEIC ACID COMPLEX
  申请人：National University Corporation Tokyo Medical and Dental University

  公开号：US20210024929A1

  公开（公告）日：2021-01-28

  Developed and provided is: a nucleic acid agent that is efficiently delivered to the central nervous system, to which drug delivery is inhibited by the blood brain barrier mechanism, and that provides an antisense effect to a target transcription product at the delivery site; and a composition containing such a nucleic acid agent. Provided is a double-stranded nucleic acid complex consisting of a first nucleic acid strand and a second nucleic acid strand that are annealed to each other; wherein the first nucleic acid strand hybridizes with part of a target transcription product and has an antisense effect on the target transcription product; and wherein the second nucleic acid strand includes a base sequence complementary to the first nucleic acid strand and is conjugated to a phosphatidylethanolamine or an analog thereof.
• US8987459B2
  申请人：——

  公开号：US8987459B2

  公开（公告）日：2015-03-24