(7S)-7-methylnonanal

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (7S)-7-methylnonanal
• 化学式: C₁₀H₂₀O
• 分子量: 156.26
• InChiKey: VQUWUMZTVSFSMW-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Polymyxins, compositions, methods of making and methods of use
  申请人：XELLIA PHARMACEUTICALS APS

  公开号：US10640536B2

  公开（公告）日：2020-05-05

  Disclosed herein is a composition comprising at least one polymyxin or a salt thereof represented by formula (I) wherein R1 is an aliphatic linear or branched C6-C10 acyl group, or (I′) R5 is —CH(CH3)2, —CH2CH(CH3)2, —CH(CH3)CH2CH3, or —CH2C6H5; R6 is —CH(CH3)2, —CH2CH(CH3)2, or —CH(CH3)CH2CH3; each of R2, R3, R4, R7 and R8 is either —(CH2)xCH2NH2 or —(CH2)xCH2N(CH2SO3M)2; wherein x is 0 or 1; wherein M is a monovalent cation; and wherein at least three of R2, R3, R4, R7 and R8 are —(CH2)xCH2N(CH2SO3M)2.

  本发明公开了一种组合物，该组合物包含至少一种由式(I)代表的多粘菌素或其盐 其中R1是脂肪族直链或支链C6-C10酰基，或(I′) R5是-CH(CH3)2、- CH( )2、-CH( ) 或- C6H5；R6是-CH( )2、- CH( )2或-CH( ) ；R2、R3、R4、R7和R8各自是-(CH2)x NH2或-( )x N( SO3M)2；其中x是0或1；其中M是一价阳离子；且R2、R3、R4、R7和R8中至少有三个是-( )x N( SO3M)2。
• POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE
  申请人：Xellia Pharmaceuticals ApS

  公开号：EP2943503A1

  公开（公告）日：2015-11-18
• [EN] POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE<br/>[FR] POLYMYXINES, COMPOSITIONS, PROCÉDÉS DE FABRICATION ET PROCÉDÉS D'UTILISATION
  申请人：XELLIA PHARMACEUTICALS APS

  公开号：WO2014108469A1

  公开（公告）日：2014-07-17

  Disclosed herein is a composition comprising at least one polymyxin or a salt thereof represented by formula (I) wherein R1 is an aliphatic linear or branched C6-C10 acyl group, or (I') R5 is -CH(CH3)2, -CH2CH(CH3)2, -CH(CH3)CH2CH3, or -CH2C6H5; R6 is -CH(CH3)2, -CH2CH(CH3)2, or -CH(CH3)CH2CH3; each of R2, R3, R4, R7and R8 is either -(CH2)XCH2NH2 or -(CH2)xCH2N(CH2SO3M)2; wherein x is 0 or 1; wherein M is a monovalent cation; and wherein at least three of R2, R3, R4, R7and R8 are -(CH2)xCH2N(CH2SO3M)2.