(2S,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal;[(2S,3S,4S,5S)-1,2,3,4,5-pentahydroxy-6-oxohexyl] dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal;[(2S,3S,4S,5S)-1,2,3,4,5-pentahydroxy-6-oxohexyl] dihydrogen phosphate
• 化学式: C12H25O16P
• 分子量: 456.29
• InChiKey: ADPFGVGNSFUKHF-QJGMBTOESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.32
• 重原子数：
  29
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  303
• 氢给体数：
  12
• 氢受体数：
  16

文献信息

• [EN] BRANCHED PEG MOLECULES AND RELATED COMPOSITIONS AND METHODS<br/>[FR] MOLÉCULES DE PEG RAMIFIÉ, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
  申请人：PHASERX INC

  公开号：WO2018126084A1

  公开（公告）日：2018-07-05

  Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.

  揭示了分支聚乙二醇（PEG）分子，包括分支PEG-脂质和分支PEG-蛋白质，以及制备分支PEG分子的相关组合物和方法。还公开了相关的组合物、系统和方法，用于体内传递治疗和诊断试剂。
• [EN] BLOCK COPOLYMERS AND THEIR CONJUGATES OR COMPLEXES WITH OLIGONUCLEOTIDES<br/>[FR] COPOLYMÈRES SÉQUENCÉS ET LEUR CONJUGUÉS OU COMPLEXES AVEC DES OLIGONUCLÉOTIDES
  申请人：PHASERX INC

  公开号：WO2015017519A1

  公开（公告）日：2015-02-05

  Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

  本文描述了嵌段共聚物以及制备和利用这种共聚物的方法。所述的嵌段共聚物破坏细胞膜，包括细胞外膜、细胞内膜、囊泡、细胞器、内体、脂质体或红细胞。在某些情况下，该嵌段共聚物会破坏膜并进入细胞内环境。在具体示例中，该嵌段共聚物具有内体溶解作用，并能够将寡核苷酸（例如mRNA）传递到细胞中。还公开了包含嵌段共聚物和寡核苷酸（例如mRNA）的组合物。
• Method for selection of high M6P recombinant proteins
  申请人：Amicus Therapeutics, Inc.

  公开号：US10227577B2

  公开（公告）日：2019-03-12

  Methods for the production, capturing and purification of recombinant human lysosomal proteins are described. Such recombinant human lysosomal proteins can have high content of mannose-6-phosphate residues. Also described are pharmaceutical compositions comprising such recombinant human lysosomal proteins, as well as methods of treatment and uses of such recombinant human lysosomal proteins.

  本文介绍了生产、捕获和纯化重组人溶酶体蛋白的方法。这种重组人溶酶体蛋白可以具有高含量的甘露糖-6-磷酸残基。还描述了包含这种重组人溶酶体蛋白的药物组合物，以及这种重组人溶酶体蛋白的治疗方法和用途。
• Gastrointestinal tract detection methods, devices and systems
  申请人：Progenity Inc.

  公开号：US10610104B2

  公开（公告）日：2020-04-07

  The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

  本公开涉及胃肠道（GI）检测方法、装置和系统。
• Block copolymers
  申请人：GENEVANT SCIENCES GMBH

  公开号：US10646582B2

  公开（公告）日：2020-05-12

  Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

  本文描述的是嵌段共聚物，以及制造和利用这种共聚物的方法。所述嵌段共聚物可破坏细胞膜，包括细胞外膜、细胞内膜、囊泡、细胞器、内体、脂质体或红细胞。优选地，在某些情况下，嵌段共聚物会破坏膜并进入细胞内环境。在具体例子中，嵌段共聚物具有内溶性，能够将寡核苷酸（如 mRNA）输送到细胞中。此外，还公开了由嵌段共聚物和寡核苷酸（如 mRNA）组成的组合物。