tert-butyl 4-[[(2R,3R,4S,4aS,8aS)-4-(3,5-dihydroxybenzoyl)-3,4a,8,8-tetramethyl-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]carbamoyl]piperidine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-butyl 4-[[(2R,3R,4S,4aS,8aS)-4-(3,5-dihydroxybenzoyl)-3,4a,8,8-tetramethyl-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]carbamoyl]piperidine-1-carboxylate
• 化学式: C₃₂H₄₈N₂O₆
• 分子量: 556.7
• InChiKey: HZQOHCKCPPTZCD-KUFBGVLTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• SHIP1 MODULATORS AND METHODS RELATED THERETO
  申请人：Aquinox Pharmaceuticals (Canada) Inc.

  公开号：EP2943470A1

  公开（公告）日：2015-11-18
• [EN] SHIP1 MODULATORS AND METHODS RELATED THERETO<br/>[FR] MODULATEURS DE SHIP1 ET PROCÉDÉS ASSOCIÉS
  申请人：AQUINOX PHARMACEUTICALS INC

  公开号：WO2014110036A1

  公开（公告）日：2014-07-17

  Compounds of formula (I): [Formula should be inserted here]; where [Formula should be inserted here], n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.