ethyl 2-hydroxy-4-oxopent-2-enoate | 53120-38-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 2-hydroxy-4-oxopent-2-enoate
• CAS: 53120-38-0
• 化学式: C₇H₁₀O₄
• 分子量: 158.154
• InChiKey: JTJFWJIHXKWLNS-UHFFFAOYSA-N

物化性质

• 沸点：
  286.7±40.0 °C(Predicted)
• 密度：
  1.166±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 2-hydroxy-4-oxopent-2-enoate 在 三氧化二氮 作用下， 以 乙醇 为溶剂， 生成 ethyl 3-(hydroxyimino)-2,4-dioxopentanoate
  参考文献：
  名称：

  Synthesis of novel 2,3-substituted-2,4-dihydro-pyrazolo[4,3-d]pyrimidine-5,7-diones

  摘要：

  Novel 2,3-substituted-2,4-dihydro-pyrazolo[4,3-d]pyrimidine-5,7-diones were successfully synthesized with moderate to good yields using a new synthetic approach. The structures of the regio-isomers in this series were determined by single crystal X-ray analysis and NMR spectra. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.098
• 作为产物：
  描述：

  草酸二乙酯 、 丙酮 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 4.33h， 生成 ethyl 2-hydroxy-4-oxopent-2-enoate
  参考文献：
  名称：

  Synthesis of novel 2,3-substituted-2,4-dihydro-pyrazolo[4,3-d]pyrimidine-5,7-diones

  摘要：

  Novel 2,3-substituted-2,4-dihydro-pyrazolo[4,3-d]pyrimidine-5,7-diones were successfully synthesized with moderate to good yields using a new synthetic approach. The structures of the regio-isomers in this series were determined by single crystal X-ray analysis and NMR spectra. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.098

文献信息

• “On water” synthesis of N-unsubstituted pyrazoles: semicarbazide hydrochloride as an alternative to hydrazine for preparation of pyrazole-3-carboxylate derivatives and 3,5-disubstituted pyrazoles
  作者：Violeta Marković、Milan D. Joksović

  DOI：10.1039/c4gc02028f

  日期：——

  A green, simple and highly efficient method for the synthesis of pyrazole-3-carboxylates and 3,5-disubstituted pyrazoles by cyclization of 4-aryl(hetaryl, alkyl)-2,4-diketoesters and 1,3-diketones with semicarbazide hydrochloride under “on water” conditions has been developed. This method also does not require toxic hydrazine and product purification, eliminating the use of toxic liquid chemicals.

  一种绿色，简单且高效的方法，通过用氨基脲盐酸盐将4-芳基（杂芳基，烷基）-2,4-二酮酸酯和1,3-二酮环化，合成吡唑-3-羧酸酯和3,5-二取代的吡唑在“水上”条件下已经开发出来。该方法也不需要毒性肼和产物纯化，从而消除了对有毒液体化学物质的使用。
• Method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof
  申请人：Mioskowski Charles

  公开号：US20060205817A1

  公开（公告）日：2006-09-14

  The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in conditions directly resulting in the derivatives of formula (I), or in obtaining at least a lactone of structure (III) in racemic form(s), or a enantiomerically enriched mixture, followed by opening, in basic conditions, in an aprotic or protic solvent, the desired lactone(s) and, optionally, separating the desired form. The invention is useful for preparing in particular (2S, 3R, 4S)-4-hydroxyisoleucine

  本发明涉及一种制备4-羟基异亮氨酸对映体和衍生物的方法，其通式为(I)，其特征在于通过还原式(II)的异噁唑衍生物，在直接条件下制备通式(I)的衍生物，或者获得至少一种外消旋的内酯(III)或对映富集混合物，然后在无水或有水的碱性条件下开环，得到所需的内酯，并可选地分离所需的形式。该发明特别适用于制备(2S,3R,4S)-4-羟基异亮氨酸。