(2-Pyridin-4-yl-1,3-oxazolidin-4-yl)-(3,4,5-trimethoxyphenyl)methanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-Pyridin-4-yl-1,3-oxazolidin-4-yl)-(3,4,5-trimethoxyphenyl)methanone
• 英文别名: (2-pyridin-4-yl-1,3-oxazolidin-4-yl)-(3,4,5-trimethoxyphenyl)methanone
• 化学式: C₁₈H₂₀N₂O₅
• 分子量: 344.4
• InChiKey: GGEGYADGDBQKBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  78.9
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• COMPOUNDS FOR TREATMENT OF CANCER
  申请人：GTx, Inc.

  公开号：US20140213623A1

  公开（公告）日：2014-07-31

  The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.

  本发明涉及一种公式XXII的化合物和一种公式17ya的化合物，它们在本规范的任何地方都有定义，涉及包含它们的组合物以及在治疗各种癌症中使用它们的方法。
• COMPOUND FOR TREATMENT OF CANCER
  申请人：University of Tennessee Research Foundation

  公开号：EP2959900A1

  公开（公告）日：2015-12-30

  A compound, wherein the compound is (2-(1H-indol-3-yl)imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone. A pharmaceutical composition comprising the compound is (2-(1H-indol-3-yl)imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone and a pharmaceutically acceptable carrier. The compound (2-(1H-indol-3-yl)imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone for use in treating prostate cancer, breast cancer, ovarian cancer, skin cancer, lung cancer, colon cancer, leukemia, renal cancer or CNS cancer, or a combination thereof.

  一种化合物，其中化合物为(2-(1H-吲哚-3-基)咪唑-4-基)(3,4,5-三甲氧基苯基)甲酮。 一种药物组合物，包含化合物 (2-(1H-吲哚-3-基)咪唑-4-基)(3,4,5-三甲氧基苯基)甲酮和药学上可接受的载体。 (2-(1H-吲哚-3-基)咪唑-4-基)(3,4,5-三甲氧基苯基)甲酮化合物用于治疗前列腺癌、乳腺癌、卵巢癌、皮肤癌、肺癌、结肠癌、白血病、肾癌或中枢神经系统癌症，或它们的组合。
• Compounds for treatment of cancer
  申请人：University of Tennessee Research Foundation

  公开号：US10301285B2

  公开（公告）日：2019-05-28

  The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.

  本发明涉及一种式 XXII 化合物和一种式 17ya 化合物（在说明书的任何地方都有定义），涉及一种包含这些化合物的组合物，还涉及一种将其用于治疗各种癌症的方法。
• US9029408B2
  申请人：——

  公开号：US9029408B2

  公开（公告）日：2015-05-12