3-ethyl-3-[(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoxy]pentan-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-ethyl-3-[(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoxy]pentan-2-one
• 化学式: C₂₇H₄₄O₂
• 分子量: 400.6
• InChiKey: JYUXMHOEPWOCLZ-QXPWYRSVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  29
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS
  申请人：PRONOVA BIOPHARMA NORGE AS

  公开号：US20140221439A1

  公开（公告）日：2014-08-07

  The present disclosure relates to lipid compounds of the general formula (I): R 1 —O—C(R 2 )(R 3 )—X  (I) wherein R 1 is a C 10 -C 22 alkyl group, a C 10 -C 22 alkenyl group having 1-6 double bonds, or a C 10 -C 22 alkynyl group having 1-6 triple bonds; R 2 and R 3 are the same or different and may be chosen from different substituents; and X is a carboxylic acid or a derivative thereof, such as a carboxylic ester, a carboxylic anhydride, a phospholipid, triglyceride, or a carboxamide; or a pharmaceutically acceptable salt, solvate, solvate of such salt, or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic, and inflammatory disease area.

  本公开涉及一般式（I）的脂质化合物：R1-O-C(R2)(R3)-X（I），其中R1为C10-C22烷基、具有1-6个双键的C10-C22烯基或具有1-6个三键的C10-C22炔基；R2和R3相同或不同，可以选择不同的取代基；X为羧酸或其衍生物，例如羧酸酯、羧酸酐、磷脂、甘油三酯或羧酰胺；或其药学上可接受的盐、溶剂、该盐的溶剂或其前药。本公开还涉及包含至少一种本公开所述化合物的制药组合物和脂质组合物，以及用于作为药物或用于治疗，特别是用于治疗与心血管、代谢和炎症疾病相关的疾病的这样的化合物。